Medical Research Center, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Precision Medicine in Oncology (PrMiO), Department of Pathology, Erasmus MC Cancer Institute, Erasmus MC, Rotterdam, the Netherlands; Nanomedicine Innovation Center Erasmus (NICE), Erasmus MC, Rotterdam, the Netherlands.
Adv Colloid Interface Sci. 2023 Nov;321:103007. doi: 10.1016/j.cis.2023.103007. Epub 2023 Sep 25.
It is well known that metal-organic framework (MOF) nanostructures have unique characteristics such as high porosity, large surface areas and adjustable functionalities, so they are ideal candidates for developing drug delivery systems (DDSs) as well as theranostic platforms in cancer treatment. Despite the large number of MOF nanostructures that have been discovered, conventional MOF-derived nanosystems only have a single biofunctional MOF source with poor colloidal stability. Accordingly, developing core-shell MOF nanostructures with good colloidal stability is a useful method for generating efficient drug delivery, multimodal imaging and synergistic therapeutic systems. The preparation of core-shell MOF nanostructures has been done with a variety of materials, but inorganic nanoparticles (NPs) are highly effective for drug delivery and imaging-guided tumor treatment. Herein, we aimed to overview the synthesis of core-shell inorganic NP@MOF nanostructures followed by the application of core-shell MOFs derived from magnetic, quantum dots (QDs), gold (Au), and gadolinium (Gd) NPs in drug delivery and imaging-guided tumor treatment. Afterward, we surveyed different factors affecting prolonged drug delivery and cancer therapy, cellular uptake, biocompatibility, biodegradability, and enhanced permeation and retention (EPR) effect of core-shell MOFs. Last but not least, we discussed the challenges and the prospects of the field. We envision this article may hold great promise in providing valuable insights regarding the application of hybrid nanostructures as promising and potential candidates for multimodal imaging-guided combination cancer therapy.
众所周知，金属-有机骨架（MOF）纳米结构具有独特的特性，如高孔隙率、大表面积和可调节的功能，因此它们是开发药物传递系统（DDS）以及癌症治疗中的治疗诊断平台的理想候选物。尽管已经发现了大量的 MOF 纳米结构，但传统的 MOF 衍生的纳米系统只有单一的具有较差胶体稳定性的生物功能 MOF 来源。因此，开发具有良好胶体稳定性的核壳 MOF 纳米结构是生成高效药物传递、多模态成像和协同治疗系统的有效方法。核壳 MOF 纳米结构的制备已经使用了多种材料，但无机纳米粒子（NPs）在药物传递和成像引导的肿瘤治疗中非常有效。在此，我们旨在概述核壳无机 NP@MOF 纳米结构的合成，然后介绍源自磁性、量子点（QD）、金（Au）和钆（Gd）NPs 的核壳 MOFs 在药物传递和成像引导的肿瘤治疗中的应用。之后，我们调查了影响延长药物传递和癌症治疗、细胞摄取、生物相容性、可生物降解性以及核壳 MOFs 的增强渗透和保留（EPR）效应的不同因素。最后但同样重要的是，我们讨论了该领域的挑战和前景。我们设想这篇文章可能对应用混合纳米结构作为多模态成像引导的联合癌症治疗的有前途和潜在候选物提供有价值的见解。
