PPD 试验对肾移植候补患者 BCG 疫苗与 COVID-19 之间关系的意义。
Significance of PPD Test for the Relationship Between BCG Vaccine and COVID-19 in Patients on Kidney Transplant Waiting List.
机构信息
Urology-Kidney Transplantation Center, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Derince-Kocaeli, Turkey.
Department of Infectious Disesase, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Derince-Kocaeli, Turkey.
出版信息
Transplant Proc. 2022 Dec;54(10):2677-2679. doi: 10.1016/j.transproceed.2022.08.016. Epub 2022 Sep 6.
BACKGROUND
The aim of this study was to determine the relationship between purified protein derivative of tuberculin (PPD) values, an indicator of BCG protection, and COVID-19 disease in patients with end-stage renal disease (ESRD) on the kidney transplant waiting list.
METHODS
Age, sex, dialysis type, ERSD etiologies, and PPD values of patients on the renal transplant waiting list were recorded. SARS-CoV-2 PCR data, whether the patients were previously infected with the virus, and, if infected, the severity of the disease were noted. Data were statistically compared.
RESULTS
PCR of 87 (47.02%) of 185 patients were studied; 107 of the patients were male and 78 were female, with a mean age of 52.8 years. The test result was positive for 28 patients. Of the patients for whom PCR was studied, 41 had a negative PPD result, while 46 had a positive PPD result. There was no correlation with SARS-CoV-2 PCR positivity in patients with a PPD ≤ 5 mm and > 5 mm. However, patients with pneumonic infiltration who required hospitalization had a significantly higher PPD value.
CONCLUSIONS
The PPD measurement, which is an indicator of BCG protection, might be a significant parameter for predicting the course of the disease in SARS-CoV-2 pneumonia.
背景
本研究旨在确定结核菌素纯蛋白衍生物（PPD）值与 COVID-19 疾病在终末期肾病（ESRD）患者中的关系，这些患者在肾移植等待名单上。
方法
记录了肾移植等待名单上患者的年龄、性别、透析类型、ESRD 病因和 PPD 值。记录了 SARS-CoV-2 PCR 数据、患者是否以前感染过该病毒，以及如果感染，疾病的严重程度。对数据进行了统计学比较。
结果
对 185 名患者中的 87 名（47.02%）进行了 PCR 研究；107 名患者为男性，78 名患者为女性，平均年龄为 52.8 岁。28 名患者的检测结果为阳性。在进行 PCR 研究的患者中，41 名患者的 PPD 结果为阴性，而 46 名患者的 PPD 结果为阳性。PPD≤5mm 和>5mm 的患者与 SARS-CoV-2 PCR 阳性无相关性。然而，需要住院治疗的有肺部浸润的患者的 PPD 值明显更高。
结论
PPD 测量值是 BCG 保护的指标，可能是预测 SARS-CoV-2 肺炎患者疾病过程的重要参数。
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