Urology-Kidney Transplantation Center, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Derince-Kocaeli, Turkey.
Department of Infectious Disesase, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Derince-Kocaeli, Turkey.
Transplant Proc. 2022 Dec;54(10):2677-2679. doi: 10.1016/j.transproceed.2022.08.016. Epub 2022 Sep 6.
The aim of this study was to determine the relationship between purified protein derivative of tuberculin (PPD) values, an indicator of BCG protection, and COVID-19 disease in patients with end-stage renal disease (ESRD) on the kidney transplant waiting list.
Age, sex, dialysis type, ERSD etiologies, and PPD values of patients on the renal transplant waiting list were recorded. SARS-CoV-2 PCR data, whether the patients were previously infected with the virus, and, if infected, the severity of the disease were noted. Data were statistically compared.
PCR of 87 (47.02%) of 185 patients were studied; 107 of the patients were male and 78 were female, with a mean age of 52.8 years. The test result was positive for 28 patients. Of the patients for whom PCR was studied, 41 had a negative PPD result, while 46 had a positive PPD result. There was no correlation with SARS-CoV-2 PCR positivity in patients with a PPD ≤ 5 mm and > 5 mm. However, patients with pneumonic infiltration who required hospitalization had a significantly higher PPD value.
The PPD measurement, which is an indicator of BCG protection, might be a significant parameter for predicting the course of the disease in SARS-CoV-2 pneumonia.
本研究旨在确定结核菌素纯蛋白衍生物（PPD）值与 COVID-19 疾病在终末期肾病（ESRD）患者中的关系，这些患者在肾移植等待名单上。
记录了肾移植等待名单上患者的年龄、性别、透析类型、ESRD 病因和 PPD 值。记录了 SARS-CoV-2 PCR 数据、患者是否以前感染过该病毒，以及如果感染，疾病的严重程度。对数据进行了统计学比较。
对 185 名患者中的 87 名（47.02%）进行了 PCR 研究；107 名患者为男性，78 名患者为女性，平均年龄为 52.8 岁。28 名患者的检测结果为阳性。在进行 PCR 研究的患者中，41 名患者的 PPD 结果为阴性，而 46 名患者的 PPD 结果为阳性。PPD≤5mm 和>5mm 的患者与 SARS-CoV-2 PCR 阳性无相关性。然而，需要住院治疗的有肺部浸润的患者的 PPD 值明显更高。
PPD 测量值是 BCG 保护的指标，可能是预测 SARS-CoV-2 肺炎患者疾病过程的重要参数。
