Sharan Jitendra, Shivakumar Indumathi, Shivakumar Arunachalam, Kamal Vineet Kumar, Chaudhari Prabhat Kumar, Challasany Srikrishna, Marya Anand
Unit of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Department of Prosthodontics, Faculty of Dentistry, SEGi University, Selangor, Malaysia.
J Oral Biol Craniofac Res. 2024 Mar-Apr;14(2):192-200. doi: 10.1016/j.jobcr.2024.02.005. Epub 2024 Feb 28.
This review synthesizes the available evidence pertinent to the effect of platelet-rich fibrin on the rate of orthodontic tooth movement during comprehensive orthodontic treatment.
This review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Nine electronic databases were searched until January 2024 without restrictions, followed by a hand search of the reference lists. Controlled randomized split-mouth human studies assessing the effect of platelet-rich fibrin on the rate of orthodontic tooth movement were included. All relevant data from the included studies were extracted and pooled for qualitative and quantitative analysis. Risk-of-Bias was assessed using the Cochrane Risk of Bias tool. The certainty of the evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluation tool.
From 515 studies, eleven randomized clinical trials were included for qualitative analysis and nine for quantitative analysis. The certainty of the evidence for these studies was low to moderate. The overall risk of bias for most studies was of some concern. The pooled estimate of the data from ten studies has a mean revealed difference of 1.31 (0.13-2.48) at a 95 % confidence interval with significant heterogeneity.
This systematic review suggest that platelet-rich fibrin enhances the orthodontic tooth movement rate, but the evidence quality was moderate. Further, based on the currently available evidence, the effectiveness of platelet-rich fibrin on the acceleration of orthodontic tooth movement could not be fully established.
PROSPERO: (CRD42021261836).
本综述综合了与富血小板纤维蛋白对综合正畸治疗中牙齿移动速率的影响相关的现有证据。
本综述遵循系统评价和Meta分析的首选报告项目指南。检索了9个电子数据库直至2024年1月，无任何限制，随后对参考文献列表进行了手工检索。纳入评估富血小板纤维蛋白对正畸牙齿移动速率影响的对照随机分口人体研究。提取并汇总纳入研究的所有相关数据，进行定性和定量分析。使用Cochrane偏倚风险工具评估偏倚风险。使用推荐分级、评估、制定和评价工具对证据的确定性进行分级。
从515项研究中，纳入11项随机临床试验进行定性分析，9项进行定量分析。这些研究证据的确定性为低到中等。大多数研究的总体偏倚风险存在一定问题。来自10项研究的数据汇总估计显示，在95%置信区间内平均差异为1.31（0.13 - 2.48），具有显著异质性。
本系统评价表明富血小板纤维蛋白可提高正畸牙齿移动速率，但证据质量为中等。此外，基于目前可得的证据，富血小板纤维蛋白对加速正畸牙齿移动的有效性尚未完全确立。
PROSPERO：（CRD42021261836）
