Jones L D, Davies C R, Steele G M, Nuttall P A
Science. 1987 Aug 14;237(4816):775-7. doi: 10.1126/science.3616608.
In nature, infected and uninfected arthropod vectors often feed together on an animal. In mimicking this scenario in the laboratory, uninfected vectors were found to acquire virus while cofeeding on the same host as infected vectors. However, the vertebrate host on which they fed did not develop detectable levels of virus in its blood. These observations were made with Thogoto virus, an influenza-like virus of medical and veterinary significance. Rhipicephalus appendiculatus ticks were used as the vector and guinea pigs as the vertebrate host. The results demonstrate that a vertebrate that is apparently refractory to infection by an arthropod-borne virus can still play an important role in the epidemiology of the virus, and they suggest a novel mode of arthropod-borne virus transmission.
在自然界中，受感染和未受感染的节肢动物媒介常常会一起叮咬动物。在实验室模拟这种情况时，发现未受感染的媒介在与受感染的媒介共同叮咬同一宿主时会感染病毒。然而，它们所叮咬的脊椎动物宿主血液中并未出现可检测到的病毒水平。这些观察结果是使用托高托病毒得出的，这是一种具有医学和兽医学意义的类流感病毒。用长角血蜱作为媒介，豚鼠作为脊椎动物宿主。结果表明，一种看似对虫媒病毒感染具有抵抗力的脊椎动物仍可在该病毒的流行病学中发挥重要作用，并且这些结果提示了一种新的虫媒病毒传播模式。
