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蜱传播虫媒病毒感染及其向脊椎动物宿主传播所涉及的潜在机制。

Potential mechanisms implied in tick infection by arboviruses and their transmission to vertebrate hosts.

作者信息

Yuan Chuanfei, Xu Qiong, Ning Yunjia, Xia Qianfeng

机构信息

NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, China.

State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.

出版信息

Integr Zool. 2025 Mar;20(2):315-330. doi: 10.1111/1749-4877.12875. Epub 2024 Jul 17.

DOI:10.1111/1749-4877.12875
PMID:39016029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11897945/
Abstract

Ticks can transmit many pathogens, including arboviruses, to their vertebrate hosts. Arboviruses must overcome or evade defense mechanisms during their passage from the tick gut to the hemolymph, salivary glands, and the feeding site in the host skin. This review summarizes current knowledge of defense mechanisms in specific tick tissues and at the feeding site in the host skin. We discuss the possible roles of these defense mechanisms in viral infection and transmission. The responses of tick salivary proteins to arbovirus infection are also discussed. This review provides information that may help accelerate research on virus-tick interactions.

摘要

蜱虫能够将包括虫媒病毒在内的多种病原体传播给它们的脊椎动物宿主。虫媒病毒在从蜱虫肠道传播至血淋巴、唾液腺以及宿主皮肤内的取食部位的过程中，必须克服或规避防御机制。本综述总结了关于蜱虫特定组织以及宿主皮肤取食部位防御机制的现有知识。我们讨论了这些防御机制在病毒感染和传播中可能发挥的作用。还讨论了蜱虫唾液蛋白对虫媒病毒感染的反应。本综述提供的信息可能有助于加速对病毒与蜱虫相互作用的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0124/11897945/7172658d9823/INZ2-20-315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0124/11897945/7172658d9823/INZ2-20-315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0124/11897945/7172658d9823/INZ2-20-315-g002.jpg

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