Department of Family Medicine, Seoul National University Hospital, Seoul National University School of Medicine, Seoul, Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
Cancer Epidemiol Biomarkers Prev. 2022 Dec 5;31(12):2228-2236. doi: 10.1158/1055-9965.EPI-22-0703.
Metabolic syndrome (MetS) is believed to increase the risk of esophageal cancer. However, most studies have been conducted in Western countries, focusing on esophageal adenocarcinoma (EAC). We aimed to investigate the association between MetS and risk of esophageal cancer in nationally representative large dataset in Korea, where esophageal squamous cell carcinoma (ESCC) is predominant.
We analyzed the health examinations and claims data from the Korean National Health Insurance Service (NHIS). A total of 6,795,738 subjects who received an NHIS provided health examination in 2009 (index year) were included. Cox proportional hazards models were used to estimate multivariable adjusted HRs (aHR) and 95% confidence intervals (CI) for the association of MetS and its components (elevated waist circumference, blood pressure, triglycerides, fasting blood glucose, reduced high-density lipoprotein cholesterol) with the risk of esophageal cancer.
During a mean (± SD) follow-up of 8.2 (± 1.1) years, 6,414 cases of esophageal cancer occurred. MetS was associated with an increased risk of esophageal cancer (aHR, 1.11; 95% CI, 1.05-1.18). Among the components of MetS, elevated waist circumference (aHR, 1.24; 95% CI, 1.16-1.33), high blood pressure (aHR, 1.29; 95% CI, 1.22-1.37), and fasting blood glucose (aHR, 1.16; 95% CI, 1.11-1.22) were associated with increased risk of esophageal cancer.
MetS was associated with an increased risk of esophageal cancer.
Our findings suggest that individuals with MetS may be at increased risk for esophageal cancer, specifically ESCC. Further studies are needed to establish the relationship between MetS and esophageal cancer.
代谢综合征（MetS）被认为会增加食管癌的风险。然而，大多数研究都是在西方国家进行的，主要集中在食管腺癌（EAC）上。我们旨在通过韩国具有全国代表性的大型数据集，调查 MetS 与食管癌风险之间的关系，因为韩国以食管鳞状细胞癌（ESCC）为主。
我们分析了韩国国家健康保险服务（NHIS）的体检和索赔数据。共有 6795738 名于 2009 年（索引年）接受 NHIS 体检的受试者纳入本研究。使用 Cox 比例风险模型来估计 MetS 及其组分（腰围升高、血压、甘油三酯、空腹血糖、高密度脂蛋白胆固醇降低）与食管癌风险之间的多变量调整后的 HR（aHR）和 95%置信区间（CI）。
在平均（±SD）8.2（±1.1）年的随访期间，有 6414 例食管癌发生。MetS 与食管癌风险增加相关（aHR，1.11；95%CI，1.05-1.18）。在 MetS 的组分中，腰围升高（aHR，1.24；95%CI，1.16-1.33）、高血压（aHR，1.29；95%CI，1.22-1.37）和空腹血糖（aHR，1.16；95%CI，1.11-1.22）与食管癌风险增加相关。
MetS 与食管癌风险增加相关。
我们的研究结果表明，患有 MetS 的个体可能面临更高的食管癌风险，特别是 ESCC。需要进一步的研究来确定 MetS 与食管癌之间的关系。
