Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Institute for Flow in Additively Manufactured Porous Media, Hochschule Heilbronn, Heilbronn, Germany.
Indoor Air. 2022 Sep;32(9):e13115. doi: 10.1111/ina.13115.
Surface residing SARS-CoV-2 is efficiently inactivated by UV-C irradiation. This raises the question whether UV-C-based technologies are also suitable to decontaminate SARS-CoV-2- containing aerosols and which doses are needed to achieve inactivation. Here, we designed a test bench to generate aerosolized SARS-CoV-2 and exposed the aerosols to a defined UV-C dose. Our results demonstrate that the exposure of aerosolized SARS-CoV-2 with a low average dose in the order of 0.42-0.51 mJ/cm UV-C at 254 nm resulted in more than 99.9% reduction in viral titers. Altogether, UV-C-based decontamination of aerosols seems highly effective to achieve a significant reduction in SARS-CoV-2 infectivity.
表面附着的 SARS-CoV-2 可被 UV-C 照射有效灭活。这就提出了一个问题，即基于 UV-C 的技术是否也适用于清除含 SARS-CoV-2 的气溶胶，以及需要多大剂量才能达到灭活效果。在此，我们设计了一个试验台来产生气溶胶化的 SARS-CoV-2，并将气溶胶暴露于规定的 UV-C 剂量下。我们的结果表明，将 254nm 处低平均剂量（约 0.42-0.51mJ/cm UV-C）的气溶胶化 SARS-CoV-2 暴露于其中，可使病毒滴度降低 99.9%以上。总之，基于 UV-C 的气溶胶消毒似乎非常有效，可以显著降低 SARS-CoV-2 的感染性。
