Bhunya S P, Pati P C
Laboratory of Genetic Toxicology, P.G. Department of Zoology, Utkal University, Orissa, India.
Toxicol Lett. 1988 Jun;41(3):223-30. doi: 10.1016/0378-4274(88)90058-6.
The genotoxicity of cypermethrin, a synthetic pyrethroid insecticide, has been studied in vivo in mice. Bone marrow chromosome aberrations were not dose, time or route dependent, but most of the results differed significantly from controls except after 6 and 24 h of treatment using the i.p. and s.c. routes, respectively. In the micronucleus test, the occurrence of polychromatic erythrocytes with micronuclei increased slightly with dose, but was significantly higher than controls at all dose levels. Only a marginal difference in the incidence of sperm abnormalities was noted with the three doses of cypermethrin tested. However, all results differed significantly from the respective control values.
氯氰菊酯是一种合成拟除虫菊酯类杀虫剂，其遗传毒性已在小鼠体内进行了研究。骨髓染色体畸变与剂量、时间或给药途径无关，但除分别采用腹腔注射和皮下注射途径给药6小时和24小时后的结果外，大多数结果与对照组有显著差异。在微核试验中，含微核的多染性红细胞的发生率随剂量略有增加，但在所有剂量水平均显著高于对照组。在所测试的三剂氯氰菊酯中，仅发现精子异常发生率有微小差异。然而，所有结果与各自的对照值均有显著差异。
