Fan Lijuan, Gao Yiqi, Zhou Jie, Hu Hantong, Gao Hong
The Third Clinical College, Zhejiang Chinese Medical University, Hangzhou City, People's Republic of China.
Department of Traditional Therapy Centre, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, People's Republic of China.
J Pain Res. 2022 Sep 21;15:2957-2965. doi: 10.2147/JPR.S383968. eCollection 2022.
Tinnitus accounts for a significant proportion of the factors that cause insomnia, and insomnia, in turn, aggravates tinnitus. Given that tinnitus and insomnia have a bidirectional relationship, tinnitus-associated insomnia is prevalent. Nonetheless, current treatments including medication and psychological therapies for tinnitus-associated insomnia do not yield satisfactory efficacy, thereby making it challenging to manage. Although acupuncture is a potentially effective treatment option, the current evidence on the efficacy and safety of acupuncture for tinnitus-associated insomnia remains inconclusive. Therefore, this systematic review and analysis protocol aims to investigate whether acupuncture is beneficial for tinnitus-associated insomnia with an acceptable safety profile.
Nine mainstream English-language and Chinese-language databases will be searched to include qualified RCTs and meta-analyses will be conducted by combining extracted data using RevMan 5.3. The risk of bias 2.0 tool recommended by Cochrane will be adopted to evaluate the methodological quality of the included RCTs. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach will be utilized to appraise the strength and certainty of evidence. Where available, we will also perform sensitivity analyses, publication bias and subgroup analysis.
Expected results from our systematic review and meta-analysis will verify the efficacy and safety of acupuncture in tinnitus-associated insomnia. The evidence generated by this review will help patients and clinicians make informed treatment decisions.
耳鸣在导致失眠的诸多因素中占相当大的比例，而失眠反过来又会加重耳鸣。鉴于耳鸣与失眠存在双向关系，与耳鸣相关的失眠很常见。然而，目前针对与耳鸣相关的失眠的治疗方法，包括药物治疗和心理治疗，效果并不理想，因此治疗颇具挑战性。尽管针灸是一种潜在有效的治疗选择，但目前关于针灸治疗与耳鸣相关失眠的疗效和安全性的证据仍不明确。因此，本系统评价和分析方案旨在研究针灸对与耳鸣相关的失眠是否有益且具有可接受的安全性。
将检索九个主流英文和中文数据库，纳入合格的随机对照试验，并使用RevMan 5.3对提取的数据进行荟萃分析。将采用Cochrane推荐的偏倚风险2.0工具评估纳入的随机对照试验的方法学质量。将运用推荐分级、评估、制定和评价（GRADE）方法评估证据的强度和确定性。如有可能，我们还将进行敏感性分析、发表偏倚分析和亚组分析。
我们的系统评价和荟萃分析的预期结果将验证针灸治疗与耳鸣相关失眠的疗效和安全性。本评价所产生的证据将有助于患者和临床医生做出明智的治疗决策。
