Guo Pei, Xu Mingmin, Pan Jiongwei, Lin Jiayi, Hu Tiannuo, Wei Yulong, Chen Yue, Guo Yu
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu City, People's Republic of China.
School of Traditional Chinese Medicine, Jinan University, Guangzhou City, People's Republic of China.
J Pain Res. 2023 Mar 28;16:1069-1079. doi: 10.2147/JPR.S394328. eCollection 2023.
Many studies have now investigated the effects of common clinical acupoint stimulation-related therapies (ASRTs) following the meridian theory of traditional Chinese medicine for the management of insomnia. However, ASRT choice is currently based on personal clinical experience or patient preference. This study will review the common ASRTs reported in clinical trials and analyze their efficacy and safety for managing insomnia with or without co-morbidities.
English and Chinese databases will be thoroughly searched, and other potentially eligible trials will be obtained by reviewing reference lists of identified studies and previous reviews. Only randomized controlled trials (RCTs) of common clinical ASRTs to manage insomnia published in peer-reviewed journals will be considered. Sleep quality questionnaires or indices will be considered as the main outcome, while the secondary outcomes will include sleep parameters, daytime dysfunction, quality of life, and adverse effects. Two reviewers will independently investigate eligible RCTs, extract information, analyze their methodological quality, and employ Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria to evaluate the strength of the evidence. The treatment impact of various ASRTs will be calculated using meta-analysis techniques, and the degree of study heterogeneity will be assessed using Cochrane's Q and I-squared statistics. Subgroup and sensitivity analyses will be used to evaluate the reliability of the results.
Our systematic review and meta-analysis will present up-to-date evidence on: 1) which common clinical ASRTs are beneficial for the management of insomnia; and 2) whether the effects of common clinical ASRTs on insomnia vary depending on clinical, participant, and treatment characteristics.
The results of our review should help decision-makers make educated choices regarding evidence-based non-pharmacological management options for insomnia.
The International Platform of Registered Systematic Review and Meta-analysis (INPLASY), record INPLASY2021120137.
目前许多研究依据中医经络理论，对常见的临床穴位刺激相关疗法（ASRTs）治疗失眠的效果进行了调查。然而，目前ASRTs的选择是基于个人临床经验或患者偏好。本研究将回顾临床试验中报道的常见ASRTs，并分析其治疗伴有或不伴有合并症的失眠的疗效和安全性。
将全面检索英文和中文数据库，并通过查阅已识别研究的参考文献列表和以往综述来获取其他可能符合条件的试验。仅考虑发表在同行评审期刊上的关于常见临床ASRTs治疗失眠的随机对照试验（RCTs）。睡眠质量问卷或指标将被视为主要结局，而次要结局将包括睡眠参数、日间功能障碍、生活质量和不良反应。两名评审员将独立调查符合条件的RCTs，提取信息，分析其方法学质量，并采用推荐分级、评估、制定和评价（GRADE）标准来评估证据的强度。将使用荟萃分析技术计算各种ASRTs的治疗效果，并使用Cochrane的Q统计量和I²统计量评估研究异质性的程度。将进行亚组分析和敏感性分析以评估结果的可靠性。
我们的系统评价和荟萃分析将提供最新证据，以说明：1）哪些常见的临床ASRTs对失眠治疗有益；2）常见临床ASRTs对失眠的影响是否因临床、参与者和治疗特征而异。
我们综述的结果应有助于决策者对基于证据的失眠非药物管理选项做出明智选择。
国际注册系统评价和荟萃分析平台（INPLASY），注册号INPLASY2021120137。
