Qiang Liming, Li Hongpeng, Wang Zhaohui, Wan Lin, Jiang Guangfu
Department of Gastroenterology Ward, Guang'an People's Hospital, Guang'an, China.
Department of Gastrointestinal Surgery, Guang'an People's Hospital, Guang'an, China.
Front Oncol. 2022 Sep 12;12:1007509. doi: 10.3389/fonc.2022.1007509. eCollection 2022.
Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targeted therapeutic strategies should be anticipated. Autophagy, which is an evolutionarily highly conserved catabolic process, may promote tumorigenesis and development of CRC. On the contrary, autophagy can trigger programmed cell death to inhibit CRC progression. Correspondingly, several targeted therapeutic strategies have been reported in CRC, including small-molecule compounds, polypeptides, non-coding RNAs, photodynamic, and adjuvant therapies. Thus, in this review, we focus on summarizing the crucial pathways of autophagy in CRC, and further discuss the current therapeutic strategies targeting autophagy. Together, these findings may shed light on the key regulatory mechanisms of autophagy and provide more promising therapeutic approaches for the future CRC therapies.
结直肠癌（CRC）是一种常见的胃肠道恶性肿瘤，大多数临床病例在晚期才被诊断出来，遗憾的是错过了手术时机；因此，应期待阐明CRC发生发展的关键途径并发现靶向治疗策略。自噬是一种在进化上高度保守的分解代谢过程，可能促进CRC的发生和发展。相反，自噬可触发程序性细胞死亡以抑制CRC进展。相应地，在CRC中已报道了几种靶向治疗策略，包括小分子化合物、多肽、非编码RNA、光动力和辅助治疗。因此，在本综述中，我们着重总结自噬在CRC中的关键途径，并进一步讨论目前针对自噬的治疗策略。总之，这些发现可能揭示自噬的关键调控机制，并为未来的CRC治疗提供更有前景的治疗方法。
