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用于鉴定来自[此处L可能指代某种植物，原文未明确完整名称]的生物活性化合物的药理活性及气相色谱 - 质谱分析

Pharmacological activities and gas chromatography-mass spectrometry analysis for the identification of bioactive compounds from L.

作者信息

Musa Muhammad, Jan Gul, Jan Farzana Gul, Hamayun Muhammad, Irfan Muhammad, Rauf Abdur, Alsahammari Abdulrahman, Alharbi Metab, Suleria Hafiz A R, Ali Niaz

机构信息

Department of Botany, Abdul Wali Khan University, Mardan, Pakistan.

Department of Botany, University of Swabi, Swabi, Pakistan.

出版信息

Front Pharmacol. 2022 Sep 12;13:922388. doi: 10.3389/fphar.2022.922388. eCollection 2022.

DOI:10.3389/fphar.2022.922388
PMID:36172192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9511829/
Abstract

The current study aimed to assess the pharmacological potential of by evaluating the presence of biologically active compounds using the gas chromatography-mass spectrometry approach and to undertake biological activities for the effectiveness of the present compounds using standard tests. A total of 21 compounds were identified in the gas chromatography-mass spectrometry analysis of the ethyl acetate fraction in which 14 of the identified compounds are recognized for their pharmacological potential in the literature. In total, four fractions (ethyl acetate, chloroform, n-hexane, and aqueous) were evaluated for pharmacological activities. In carrageenan-induced inflammation, the chloroform fraction exhibited high anti-inflammatory activity (46.51%). Similarly, the analgesic potential of ethyl acetate fraction was the most effective (300 mg/kg) in the acetic acid-induced test. Similarly, in the formalin test, ethyl acetate fraction exhibited maximum inhibition in both early (74.35%) and late phases (88.38). Maximum inhibition of pyrexia (77.98%) was recorded for the ethyl acetate fraction (300 mg/kg). In DPPH assay, the ethyl acetate fraction revealed the highest scavenging potential among other fractions (50 μg/ml resulted in 50.40% and 100 μg/ml resulted in 66.74% scavenging).

摘要

本研究旨在通过气相色谱 - 质谱联用方法评估生物活性化合物的存在，以评估[具体物质未给出]的药理潜力，并使用标准测试对这些化合物的有效性进行生物活性研究。在乙酸乙酯馏分的气相色谱 - 质谱分析中总共鉴定出21种化合物，其中14种已在文献中因其药理潜力而被认可。总共对四个馏分（乙酸乙酯、氯仿、正己烷和水相）进行了药理活性评估。在角叉菜胶诱导的炎症中，氯仿馏分表现出高抗炎活性（46.51%）。同样，在醋酸诱导试验中，乙酸乙酯馏分的镇痛潜力在300mg/kg时最为有效。同样，在福尔马林试验中，乙酸乙酯馏分在早期（74.35%）和晚期（88.38%）均表现出最大抑制作用。乙酸乙酯馏分（300mg/kg）记录到对发热的最大抑制率（77.98%）。在DPPH测定中，乙酸乙酯馏分在其他馏分中显示出最高的清除潜力（50μg/ml导致50.40%的清除率，100μg/ml导致66.74%的清除率）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/cb50ab3cce38/fphar-13-922388-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/d188d2909504/fphar-13-922388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/33aa9b0b1272/fphar-13-922388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/5600cbddede6/fphar-13-922388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/8b16f436ba3c/fphar-13-922388-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/b7987f5e9cdd/fphar-13-922388-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/6a87d9ff7150/fphar-13-922388-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/cb50ab3cce38/fphar-13-922388-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/d188d2909504/fphar-13-922388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/33aa9b0b1272/fphar-13-922388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/5600cbddede6/fphar-13-922388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/8b16f436ba3c/fphar-13-922388-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/b7987f5e9cdd/fphar-13-922388-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/6a87d9ff7150/fphar-13-922388-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cfe/9511829/cb50ab3cce38/fphar-13-922388-g007.jpg

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