膳食纤维通过肠道微生物群衍生的短链脂肪酸对宿主健康的调节作用。
The regulatory roles of dietary fibers on host health via gut microbiota-derived short chain fatty acids.
作者信息
Xu Tong, Wu Xinyue, Liu Jia, Sun Jiayi, Wang Xiaobo, Fan Gang, Meng Xianli, Zhang Jing, Zhang Yi
机构信息
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Ethnic Medicine Academic Heritage Innovation Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Ethnic Medicine Academic Heritage Innovation Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
出版信息
Curr Opin Pharmacol. 2022 Feb;62:36-42. doi: 10.1016/j.coph.2021.11.001. Epub 2021 Dec 9.
As a component of nutraceuticals, dietary fibers (DFs) are essential for maintain human growth and health via the regulation of gut microbiota in the digestive tract. In this review, we summarize food-derived DFs and their effect on gut microbiota-derived short-chain fatty acids (SCFAs). DFs accelerate the production of SCFAs mainly by stimulating intestinal Lactobacillus, Bifidobacterium and Akkermansia to treat diabetes, obesity, cancer, inflammation and immunodeficiency. Further studies should focus on clarifying the detailed mechanism between DFs and diseases associated with gut microbiota-mediated SCFAs.
作为营养保健品的一个组成部分，膳食纤维（DFs）通过调节消化道中的肠道微生物群对维持人体生长和健康至关重要。在本综述中，我们总结了食物来源的膳食纤维及其对肠道微生物群衍生的短链脂肪酸（SCFAs）的影响。膳食纤维主要通过刺激肠道中的乳酸杆菌、双歧杆菌和阿克曼氏菌来加速短链脂肪酸的产生，从而治疗糖尿病、肥胖症、癌症、炎症和免疫缺陷。进一步的研究应集中于阐明膳食纤维与肠道微生物群介导的短链脂肪酸相关疾病之间的详细机制。
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