Qiao Huiyu, Yang Qiansu, Huo Ran, Han Hualu, Ning Zihan, Shen Rui, Song Xiaowei, Chen Huijun, Chen Shuo, Zhao Xihai
Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China.
School of Medicine, Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China.
J Magn Reson Imaging. 2023 May;57(5):1376-1389. doi: 10.1002/jmri.28445. Epub 2022 Sep 29.
T , T , and T * mappings are seldom performed in a single examination, and their values in evaluating symptomatic atherosclerosis are lacking.
To perform three-dimensional (3D) quantitative T , T , and T * mappings (SQUMA) multi-parametric imaging for carotid vessel wall and evaluate its reliability and value in assessing carotid atherosclerosis.
Prospective.
Eight healthy subjects and 20 patients with symptomatic carotid atherosclerosis.
FIELD STRENGTH/SEQUENCE: 3 T, SQUMA imaging T -, T -, and T *-mapping, multi-contrast vessel wall imaging including T - and T -weighted, time-of-flight, and SNAP sequences.
SQUMA was acquired in all subjects and multi-contrast images were acquired in healthy subjects. T , T , and T * values and lumen area (LA), wall area (WA), mean wall thickness (MeanWT), and normalized wall index (NWI) of carotid arteries were measured. SQUMA and multi-contrast measurements were compared in healthy subjects and differences in SQUMA measurements between healthy subjects and patients were assessed. The discriminative value of SQUMA measurements for symptomatic vessel was determined.
Paired t or Wilcoxon signed-rank test, independent t or Mann-Whitney U test, area under the receiver operating characteristic curve (AUC), intraclass correlation coefficients, and Bland-Altman plots. Statistically significant level, P < 0.05.
There were no significant differences in LA (P = 0.340), WA (P = 0.317), MeanWT (P = 0.088), and NWI (P = 0.091) of carotid arteries between SQUMA and multi-contrast vessel wall images. The values of T (50.9 ± 2.9 msec vs. 44.5 ± 4.2 msec), T * (28.2 ± 4.3 msec vs. 24.7 ± 2.6 msec), WA (23.7 ± 4.6 mm vs. 36.2 ± 7.7 mm ), MeanWT (0.99 ± 0.05 mm vs. 1.50 ± 0.28 mm), and NWI (40.7 ± 3.0% vs. 53.8 ± 5.4%) of carotid arteries in healthy subjects were significantly different from those in atherosclerotic patients. The combination of quantitative T , T , and T * values and MeanWT showed greatest AUC (0.81; 95% CI: 0.65-0.92) in discriminating symptomatic vessels.
Carotid MR 3D quantitative multi-parametric imaging of SQUMA enables acquisition of T , T , and T * maps, reliably measuring carotid morphology and discriminating carotid symptomatic atherosclerosis.
2 TECHNICAL EFFICACY: Stage 2.
T1、T2和T*映射很少在一次检查中同时进行，且缺乏其在评估有症状动脉粥样硬化方面的价值。
对颈动脉血管壁进行三维（3D）定量T1、T2和T*映射（SQUMA）多参数成像，并评估其在评估颈动脉粥样硬化中的可靠性和价值。
前瞻性研究。
8名健康受试者和20名有症状颈动脉粥样硬化患者。
场强/序列：3T，SQUMA成像T1、T2和T*映射，多对比度血管壁成像，包括T1加权、T2加权、时间飞跃和SNAP序列。
对所有受试者进行SQUMA成像，对健康受试者进行多对比度成像。测量颈动脉的T1、T2和T*值以及管腔面积（LA）、管壁面积（WA）、平均管壁厚度（MeanWT）和标准化管壁指数（NWI）。比较健康受试者的SQUMA和多对比度测量结果，并评估健康受试者与患者之间SQUMA测量结果的差异。确定SQUMA测量对有症状血管的鉴别价值。
配对t检验或Wilcoxon符号秩检验、独立t检验或Mann-Whitney U检验、受试者操作特征曲线下面积（AUC）、组内相关系数和Bland-Altman图。统计学显著性水平，P<0.05。
SQUMA与多对比度血管壁图像之间，颈动脉的LA（P = 0.340）、WA（P = 0.317）、MeanWT（P = 0.088）和NWI（P = 0.091）无显著差异。健康受试者颈动脉的T1（50.9±2.9毫秒对44.5±4.2毫秒）、T*（28.2±4.3毫秒对24.7±2.6毫秒）、WA（23.7±4.6平方毫米对36.2±7.7平方毫米）、MeanWT（0.99±0.05毫米对1.50±0.28毫米）和NWI（40.7±3.0%对53.8±5.4%）值与动脉粥样硬化患者有显著差异。定量T1、T2和T*值与MeanWT的组合在鉴别有症状血管方面显示出最大的AUC（0.81；95%CI：0.65 - 0.92）。
颈动脉MR 3D定量多参数SQUMA成像能够获取T1、T2和T*图，可靠地测量颈动脉形态并鉴别颈动脉有症状粥样硬化。
2级 技术效能：2级
