与系统性硬化症患者生活质量相关的因素：一项横断面研究。
Factors associated with quality of life in systemic sclerosis: a cross-sectional study.
机构信息
Department of Integrated Medical Care, Medical University of Bialystok, 7a Maria Sklodowska-Curie Street, 15-096, Bialystok, Poland.
Department of Geriatrics, Medical University of Bialystok, Bialystok, Poland.
出版信息
Qual Life Res. 2019 Dec;28(12):3347-3354. doi: 10.1007/s11136-019-02284-9. Epub 2019 Sep 3.
INTRODUCTION
Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and internal organs, leading to their failure and disturbances in the morphology and function of blood vessels. The disease affects people in different ways, and identifying how the difficulties and limitations are related to quality of life may contribute to designing helpful interventions. The aim of this study was to identify factors associated with quality of life in people with SSc.
METHODS
This was a cross-sectional study conducted in 11 rheumatic centres in Poland. Patients diagnosed with SSc were included. Quality of life was measured using the SSc Quality of Life Questionnaire (SScQoL). The following candidate factors were entered in preliminary multivariable analysis: age, place of residence, marital status, occupational status, disease type, disease duration, pain, fatigue, intestinal problems, breathing problems, Raynaud's symptoms, finger ulcerations, disease severity, functional disability, anxiety and depression. Factors that achieved statistical significance at the 10% level were then entered into a final multivariable model. Factors achieving statistical significance at the 5% level in the final model were considered to be associated with quality of life in SSc.
RESULTS
In total, 231 participants were included. Mean age (SD) was 55.82 (12.55) years, disease duration 8.39 (8.18) years and 198 (85.7%) were women. Factors associated with quality of life in SSc were functional disability (β = 2.854, p < 0.001) and anxiety (β = 0.404, p < 0.001). This model with two factors (functional disability and anxiety) explained 56.7% of the variance in patients with diffuse SSc and 73.2% in those with localized SSc.
CONCLUSIONS
Functional disability and anxiety are significantly associated with quality of life in SSc. Interventions aimed at improving either of these factors may contribute towards improving the quality of life of people with SSc.
简介
系统性硬化症（SSc）是一种结缔组织疾病，其特征为皮肤和内脏器官进行性纤维化，导致其功能衰竭以及血管形态和功能紊乱。这种疾病对不同的人有不同的影响，识别困难和限制与生活质量的关系可能有助于设计有帮助的干预措施。本研究的目的是确定与 SSc 患者生活质量相关的因素。
方法
这是一项在波兰 11 个风湿病中心进行的横断面研究。纳入了诊断为 SSc 的患者。使用 SSc 生活质量问卷（SScQoL）来衡量生活质量。初步多变量分析中纳入了以下候选因素：年龄、居住地、婚姻状况、职业状况、疾病类型、疾病持续时间、疼痛、疲劳、肠道问题、呼吸问题、雷诺现象症状、手指溃疡、疾病严重程度、功能障碍、焦虑和抑郁。在 10%水平上具有统计学意义的因素随后被纳入最终多变量模型。在最终模型中具有统计学意义的因素（5%水平）被认为与 SSc 的生活质量相关。
结果
共纳入 231 名参与者。平均年龄（标准差）为 55.82（12.55）岁，疾病持续时间为 8.39（8.18）年，198 名（85.7%）为女性。与 SSc 生活质量相关的因素是功能障碍（β=2.854，p<0.001）和焦虑（β=0.404，p<0.001）。该模型中，两个因素（功能障碍和焦虑）解释了弥漫性 SSc 患者 56.7%的方差和局限性 SSc 患者 73.2%的方差。
结论
功能障碍和焦虑与 SSc 的生活质量显著相关。旨在改善这两个因素之一的干预措施可能有助于提高 SSc 患者的生活质量。
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