[皮肤触觉感受器默克尔细胞功能的研究进展]
[Research advances on the function of skin touch receptor Merkel cells].
作者信息
Yuan H P, Ding Y Y, Zheng Y X, Zhang Y J, Liu X, Rui C, Wang C C, Xiao Y
机构信息
Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, China.
Centre for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
出版信息
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Sep 20;38(9):887-892. doi: 10.3760/cma.j.cn501120-20211209-00409.
The reconstruction of tactile function during the repair of skin damage caused by factors including burns is inseparable from the functional regeneration of tactile receptor Merkel cells. Merkel cells mainly exist in the basal layer of the epidermis and are closely connected with nerves to form Merkel cell-nerve complexes, which play an important role in biological organisms. A large number of studies have shown that Merkel cells conduct precise transmission of mechanical force stimuli through the mechanically gated ion channels PIEZO2, and perform the function of tactile receptors. In this paper, we discussed the characteristics of Merkel cells and analyzed the different subgroups that may possibly exist in this type of cells and their functions, at the same time, we investigated the animal model research of touch-related diseases and the clinical diseases related to touch, revealing the importance of Merkel cell function research.
在修复由包括烧伤在内的因素导致的皮肤损伤过程中，触觉功能的重建离不开触觉感受器默克尔细胞的功能再生。默克尔细胞主要存在于表皮基底层，与神经紧密相连形成默克尔细胞 - 神经复合体，在生物机体中发挥重要作用。大量研究表明，默克尔细胞通过机械门控离子通道PIEZO2进行机械力刺激的精确传递，并履行触觉感受器的功能。本文探讨了默克尔细胞的特性，分析了这类细胞可能存在的不同亚群及其功能，同时，研究了与触觉相关疾病的动物模型以及与触觉相关的临床疾病，揭示了默克尔细胞功能研究的重要性。
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