[Significance of scanning electron microscopy observations on cellular reactions in the biological evaluation of endoprosthetic materials].

In a scanning electron microscopic study there are described the adhesion, spreading and formation of confluent monolayers from fibroblasts and epithelioid cells on Al2O3-ceramics and cobalt-basis-alloys in relation to vitreous carbon and glass. The morphogenetic reactions of cultured cells were not significantly different in pattern, behaviour and kinetics on various biomaterials. The cells adhered, spread, migrated and proliferated on the surface of biomaterials to be tested. This allows the conclusion that this implant material is compatible with cells. The variability of properties and susceptibility of cultured cells were discussed as a criterion for biocompatibility of implant materials in preclinical test.