Research Centre for Medical Genetics, Laboratory of Genome Editing, Moscow, 115522, Russia.
Cell Tissue Res. 2022 Dec;390(3):317-333. doi: 10.1007/s00441-022-03686-x. Epub 2022 Sep 30.
Lung diseases occupy a leading position in human morbidity and are the third leading cause of death. Often the chronic forms of these diseases do not respond to therapy, so that lung transplantation is the only treatment option. The development of cellular and biotechnologies offers a new solution-the use of lung organoids for transplantation in such patients. Here, we review types of lung organoids, methods of their production and characterization, and experimental works on transplantation in vivo. These results show the promise of work in this direction. Despite the current problems associated with a low degree of cell engraftment, immune response, and insufficient differentiation, we are confident that organoid transplantation will find it is clinical application.
肺部疾病在人类发病率中占据首要位置，是导致死亡的第三大原因。这些疾病的慢性形式通常对治疗没有反应，因此肺移植是唯一的治疗选择。细胞和生物技术的发展提供了新的解决方案——在这些患者中使用肺类器官进行移植。在这里，我们回顾了肺类器官的类型、它们的生产和表征方法，以及体内移植的实验工作。这些结果显示了这一方向工作的前景。尽管目前存在一些问题，例如细胞植入程度低、免疫反应和分化不足，但我们有信心，类器官移植将找到其临床应用。
