Xie Chen, Piao Mingyi, Zhou Liwang, Tao Xinchen, Yao Yuanyuan, Jiang Baochun, Wang Xinqiang, Yan Min
Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Department of Anesthesiology, The First Affiliated Hospital of Huzhou University, Huzhou, China.
J Thorac Dis. 2025 Feb 28;17(2):796-815. doi: 10.21037/jtd-24-1451. Epub 2025 Feb 27.
Lung transplantation is the only viable option for end-stage respiratory diseases, with the global prevalence of this procedure on the rise in recent years. However, it is still plagued by various complications, for which no satisfactory therapy has yet been identified. Understanding the mechanisms underlying these post-transplant complications may be beneficial to enhance patient outcomes. This study utilized bibliometric analysis to assess present publication trends and focal points in the field of animal experimental studies on lung transplantation, aiming to provide insights into potential areas for future research.
Utilizing CiteSpace software, the Online Analysis Platform of Literature Metrology, R package bibliometrix and VOSviewer, an analysis of current publication trends and hotspots in the area of animal experimental research for lung transplantation was carried out for the period spanning from 2004 to 2023. The English articles were searched in the Science Citation Index-Expanded (SCI-E) of Web of Science Core Collection (WoSCC).
A total of 995 articles on animal experimental research on lung transplantation over the past two decades were retrieved. Rats, mice and swine were the most commonly used animal models, with orthotopic lung transplantation, ischemia-reperfusion (IR), and ex vivo lung perfusion (EVLP) being the most frequently employed model of lung transplantation in animals. The leading contributed countries in this area were USA, Canada, Japan and China. Washington University and Shaf Keshavjee were acknowledged as the most influential institute and scholar, respectively. The top 10 main clusters identified through co-occurrence cluster analysis included, lung perfusion, EVLP, obliterative bronchiolitis, necroptosis, bronchiolitis obliterans, non-heart-beating donor, donation after circulatory death, xenotransplantation, hydrogen sulfide and alveolar macrophage. Current research focused on lung IR injury, lung transplant, hypoxia, and differentiation, as revealed by keyword burst detection.
Over the past 20 years, global publications on animal experimental research for lung transplantation have grown rapidly. The current research hotspots focus on lung IR injury, hypoxia and differentiation during lung transplantation. Exploring the potential synergistic effects of EVLP and necroptosis inhibition in more depth could offer valuable information for improving lung transplant outcomes. Our analysis presents a detailed overview of the current state of animal experimental research in lung transplantation, evaluating current publication trends and focal points and providing significant insights for future research efforts.
肺移植是终末期呼吸系统疾病唯一可行的治疗选择，近年来该手术在全球的普及率呈上升趋势。然而，它仍受到各种并发症的困扰，目前尚未找到令人满意的治疗方法。了解这些移植后并发症的潜在机制可能有助于改善患者预后。本研究利用文献计量分析来评估肺移植动物实验研究领域目前的发表趋势和重点，旨在为未来研究的潜在领域提供见解。
利用CiteSpace软件、文献计量在线分析平台、R包bibliometrix和VOSviewer，对2004年至2023年期间肺移植动物实验研究领域的当前发表趋势和热点进行了分析。在Web of Science核心合集（WoSCC）的科学引文索引扩展版（SCI-E）中检索英文文章。
在过去二十年中，共检索到995篇关于肺移植动物实验研究的文章。大鼠、小鼠和猪是最常用的动物模型，原位肺移植、缺血再灌注（IR）和体外肺灌注（EVLP）是动物肺移植中最常用的模型。该领域的主要贡献国家是美国、加拿大、日本和中国。华盛顿大学和沙夫·凯沙维吉分别被认为是最具影响力的机构和学者。通过共现聚类分析确定的前10个主要聚类包括肺灌注、EVLP、闭塞性细支气管炎、坏死性凋亡、闭塞性细支气管炎、非心脏跳动供体、循环死亡后捐赠、异种移植、硫化氢和肺泡巨噬细胞。关键词爆发检测显示，当前的研究集中在肺IR损伤、肺移植、缺氧和分化方面。
在过去20年中，全球关于肺移植动物实验研究的出版物迅速增加。当前的研究热点集中在肺移植过程中的肺IR损伤、缺氧和分化。更深入地探索EVLP和坏死性凋亡抑制的潜在协同效应，可能为改善肺移植结果提供有价值的信息。我们的分析详细概述了肺移植动物实验研究的现状，评估了当前的发表趋势和重点，并为未来的研究工作提供了重要见解。
