Ebeling K, Weissbach A, Nischan P
Zentralbl Gynakol. 1987;109(10):634-46.
In a population based study, 782 cases of microinvasive cervical cancer stage Ia recorded in Berlin, capital of the GDR, between 1970 and 1978 were analyzed. As the consequence of a cytological screening programme started in 1973, the percentage of stage Ia-cancer increased to 30% in 1978 and 35% in 1984. The percentage of asymptomatic cases (86%) only detectable by colposcopy and/or cytology (92%) increased also considerably. The percentage of cases histologically confirmed by cone biopsy increased from 55% to 81%. During the period analyzed, the percentage of radically treated cases (Wertheim, Schauta, combined surgery and radiotherapy) decreased to 31%. Among 459 patients only treated by conization or simple hysterectomy 7 developed recurrences and 2 died from the disease despite of an intensive second treatment. Among 323 patients treated more radically (Wertheim, Schauta, combined surgery and radiotherapy), there was no recurrence but 5 deaths by early or late treatment complications. Therefore, observed cumulative survival rates of patients treated by conization or hysterectomy were slightly higher than those of patients treated more radically.
在一项基于人群的研究中，对1970年至1978年间在民主德国首都柏林记录的782例宫颈微浸润癌Ia期病例进行了分析。由于1973年启动了细胞学筛查计划，Ia期癌症的比例在1978年增至30%，在1984年增至35%。仅通过阴道镜检查和/或细胞学检查（92%）才能检测到的无症状病例比例（86%）也大幅增加。经锥形活检组织学确诊的病例比例从55%增至81%。在分析期间，接受根治性治疗的病例（韦特海姆氏手术、绍陶氏手术、联合手术及放疗）比例降至31%。在仅接受锥形切除术或单纯子宫切除术治疗的459例患者中，7例出现复发，2例尽管接受了强化二次治疗仍死于该病。在接受更根治性治疗（韦特海姆氏手术、绍陶氏手术、联合手术及放疗）的323例患者中，无复发情况，但有5例因早期或晚期治疗并发症死亡。因此，接受锥形切除术或子宫切除术治疗的患者的观察到的累积生存率略高于接受更根治性治疗的患者。
