Malik Shiza, Ahmad Tahir, Ahsan Omar, Muhammad Khalid, Waheed Yasir
Bridging Health Foundation, Rawalpindi, Punjab 46000, Pakistan.
Industrial Biotechnology, Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, Pakistan.
Vaccines (Basel). 2023 Feb 21;11(3):500. doi: 10.3390/vaccines11030500.
Human mpox is an emerging epidemic in the world. The monkey pox virus (MPXV) belongs to the same family of zoonotic Orthopoxviridae as that of the smallpox virus and exhibits similar clinical symptomology. Information regarding its diagnostics, disease epidemiology, surveillance, preventive methods, and treatment strategies are being collated with time. The purpose of this review is to trace the recent events in the scientific platform that have defined new preventive and treatment strategies against mpox. A methodological approach has been used to gather data from the latest literature to comprehensively overview the emerging treatment options. The results portion will cover details regarding the prevention of mpox. It will also shed light on a brief description of contemporary vaccines and antiviral agents that have been evaluated for their treatment potential since the emergence of the mpox threat. These treatment options are setting the pace for controlling the widespread monkeypox infection. However, the limitations attached to these treatment strategies need to be tackled quickly to increase their efficacy so that they can be deployed on a large scale for the prevention of this epidemic becoming another pandemic in this decade.
人类猴痘是一种在全球范围内新出现的流行病。猴痘病毒（MPXV）与天花病毒同属人畜共患的正痘病毒科，临床表现相似。关于其诊断、疾病流行病学、监测、预防方法和治疗策略的信息正随着时间不断整理。本综述的目的是追溯科学平台上近期确定针对猴痘的新预防和治疗策略的事件。已采用一种方法从最新文献中收集数据，以全面概述新兴的治疗选择。结果部分将涵盖猴痘预防的详细信息。它还将简要介绍自猴痘威胁出现以来已评估其治疗潜力的当代疫苗和抗病毒药物。这些治疗选择正在为控制猴痘感染的广泛传播奠定基础。然而，需要迅速解决这些治疗策略所附带的局限性，以提高其疗效，从而能够大规模部署它们来预防这种流行病在本十年成为另一场大流行。
