Dolatkhah Neda, Toopchizadeh Vahideh, Barmaki Sahel, Salekzamani Yagoub, Najjari Afsaneh, Farshbaf-Khalili Azizeh, Dolati Sanam
Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Eur J Nutr. 2023 Mar;62(2):659-672. doi: 10.1007/s00394-022-03017-4. Epub 2022 Oct 2.
To evaluate the effect of an anti-inflammatory compared to a low-calorie diet on the physical and mental health of patients with knee OA.
In this randomized parallel clinical trial, participants were selected among overweight and obese women aged 40 years or older with mild to moderate OA. Sixty women with a ratio of 1:1 were randomly assigned to receive either low-calorie or anti-inflammatory accompanied by a low-calorie diet for two months. The dietary intake and weight of participants were measured. Study variables were assessed using the Western Ontario and McMaster Index (WOMAC), visual analog pain scale (VAS), Beck Depression Inventory (BDI-II), Beck Anxiety Inventory (BAI-I), and the Short Form 36 Health Survey Questionnaire (SF-36) to indicate the quality of life (QoL).
There was no statistically significant difference between the two groups in demographic and baseline variables except for the emotional well-being subscale of QoL. There was significant difference in anti-inflammatory compared to low-calorie diet in terms of weight (MD (95% CI): - 4.02 kg (- 6.77 to - 1.28); p = 0.005), VAS (MD (95% CI): - 0.97 (- 1.53 to - 0.41); p = 0.001), WOMAC-total score (MD (95% CI): - 9.91 (- 15.05 to - 4.78); p < 0.001), WOMAC-pain subscale (MD (95% CI): - 3.30 (- 5.30 to - 1.29); p = 0.002), WOMAC-physical function (MD(95% CI): - 5.48 (- 9.41 to - 1.53); p = 0.007), depression (p = 0.003), anxiety (p = 0.011), QoL-physical functioning (0.041), and QoL-pain (0.010) after the intervention.
An anti-inflammatory accompanied by a low-calorie diet resulted in greater weight loss and greater improvement in pain intensity, functional status, depression, anxiety, and some dimension of QoL in overweight and obese women with knee OA compared to the low-calorie diet. Trial registration number and date of registration: IRCT201610220030424N2; 2018-04-23.
评估抗炎饮食与低热量饮食相比，对膝骨关节炎患者身心健康的影响。
在这项随机平行临床试验中，从40岁及以上患有轻至中度骨关节炎的超重和肥胖女性中选取参与者。60名女性按1:1的比例随机分配，分别接受低热量饮食或抗炎饮食（同时搭配低热量饮食），为期两个月。测量参与者的饮食摄入量和体重。使用西安大略和麦克马斯特大学指数（WOMAC）、视觉模拟疼痛量表（VAS）、贝克抑郁量表（BDI-II）、贝克焦虑量表（BAI-I）以及健康调查简表36（SF-36）来评估研究变量，以表明生活质量（QoL）。
除生活质量的情感幸福子量表外，两组在人口统计学和基线变量方面无统计学显著差异。干预后，抗炎饮食组与低热量饮食组相比，在体重（MD（95%CI）：-4.02kg（-6.77至-1.28）；p = 0.005）、VAS（MD（95%CI）：-0.97（-1.53至-0.41）；p = 0.001）、WOMAC总分（MD（95%CI）：-9.91（-15.05至-4.78）；p < 0.001）、WOMAC疼痛子量表（MD（95%CI）：-3.30（-5.30至-1.29）；p = 0.002）、WOMAC身体功能（MD（95%CI）：-5.48（-9.41至-1.53）；p = 0.007）以及抑郁（p = 0.003）、焦虑（p = 0.011）、生活质量 - 身体功能（0.041）和生活质量 - 疼痛（0.010）方面存在显著差异。
与低热量饮食相比，抗炎饮食搭配低热量饮食能使超重和肥胖的膝骨关节炎女性体重减轻更多，疼痛强度、功能状态、抑郁、焦虑及生活质量的某些维度改善更明显。试验注册号及注册日期：IRCT201610220030424N2；2018 - 04 - 23。
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