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颈动脉血运重建术后失访与长期卒中及死亡风险增加相关。

Loss of follow-up after carotid revascularization is associated with worse long-term stroke and death.

机构信息

Division of Vascular and Endovascular Surgery, University of California San Diego, La Jolla, CA.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

出版信息

J Vasc Surg. 2023 Feb;77(2):548-554.e1. doi: 10.1016/j.jvs.2022.09.023. Epub 2022 Sep 29.

Abstract

OBJECTIVES

Society for Vascular Surgery practice guidelines recommend surveillance with duplex ultrasound scanning at baseline (within 3 months from discharge), every 6 months for 2 years, and annually afterward following carotid endarterectomy or carotid artery stenting. There is a growing concern regarding the significance of postoperative follow-up after several vascular procedures. We sought to determine whether 1-year loss to follow-up (LTF) after carotid revascularization was associated with worse outcomes in the Vascular Quality Initiative (VQI) linked to Vascular Implant Surveillance and Interventional Outcomes Network (VISION) database.

METHODS

All patients who underwent carotid revascularization in the VQI VISION database between 2003 and 2016 were included. LTF was defined as failure to complete 1-year follow-up in the VQI long-term follow-up dataset. Data about stroke and mortality were captured in the VISION dataset using a list of Current Procedural Terminology, International Classification of Diseases (Ninth Revision), and International Classification of Diseases (Tenth Revision) codes linked to index procedures in VQI. Kaplan-Meier life-table methods and Cox proportional hazard modeling were used to compare 5- and 10-year outcomes between patients with no LTF and those who were LTF.

RESULTS

A total of 58,840 patients were available for analysis. The 1-year LTF rate was 43.8%. Patients who were LTF were older and more frequently symptomatic, with chronic obstructive pulmonary diseases, chronic kidney diseases, and congestive heart failure. Also, patients who underwent carotid artery stenting were more likely to be LTF compared with carotid endarterectomy patients (54.5% vs 42.3%; P < .001). The incidence of postoperative (30 days) stroke was higher in the LTF group (2.9% vs 1.7%; P < .001). Cox regression analysis revealed that LTF was associated with an increased risk of long-term stroke at 5 years (hazard ratio [HR]: 1.4, 95% confidence interval [CI]: 1.2-1.6; P < .001) and 10 years (HR: 1.3, 95% CI: 1.2-1.5; P < .001). It was also associated with significantly higher mortality at 5 years (HR: 2.5, 95% CI: 2.3-2.8; P < .001) and 10 years (HR: 2.2, 95% CI: 1.9-2.5; P < .001). Stroke or death was significantly worse in the LTF group at 5 years (HR: 2.3, 95% CI: 2.1-2.5; P < .001) and up to 10 years (HR: 2.02, 95% CI: 1.8-2.3; P < .001).

CONCLUSIONS

One-year follow-up after carotid revascularization procedures was found to be associated with better stroke- and mortality-free survival. Surgeons should emphasize the importance of follow-up to all patients who undergo carotid revascularization, especially those with multiple comorbidities and postoperative neurological complications.

摘要

目的

血管外科学会的实践指南建议,在颈动脉内膜切除术或颈动脉支架置入术后,在出院后 3 个月内(基线)进行一次超声双功能扫描检查,此后每 6 个月进行一次,之后每年进行一次。对于多种血管手术后的术后随访的重要性,人们越来越关注。我们试图确定颈动脉血运重建后 1 年的失访(LTF)是否与血管质量倡议(VQI)相关联的血管植入物监测和干预结果网络(VISION)数据库中较差的结果有关。

方法

在 2003 年至 2016 年间,对 VQI VISION 数据库中接受颈动脉血运重建的所有患者进行了研究。将 LTF 定义为未能在 VQI 长期随访数据集中完成 1 年随访。使用与 VQI 中索引手术相关的当前程序术语、国际疾病分类(第九版)和国际疾病分类(第十版)代码列表,在 VISION 数据集捕获有关中风和死亡率的数据。使用 Kaplan-Meier 生命表方法和 Cox 比例风险模型来比较无 LTF 患者和 LTF 患者的 5 年和 10 年结果。

结果

共分析了 58840 名患者。1 年 LTF 率为 43.8%。LTF 患者年龄较大,更常出现症状,患有慢性阻塞性肺疾病、慢性肾脏病和充血性心力衰竭。此外,与颈动脉内膜切除术患者相比,颈动脉支架置入术患者更有可能 LTF(54.5% vs. 42.3%;P<.001)。LTF 组术后(30 天)中风的发生率更高(2.9% vs. 1.7%;P<.001)。Cox 回归分析显示,LTF 与 5 年(危险比[HR]:1.4,95%置信区间[CI]:1.2-1.6;P<.001)和 10 年(HR:1.3,95%CI:1.2-1.5;P<.001)的长期中风风险增加相关。它还与 5 年(HR:2.5,95%CI:2.3-2.8;P<.001)和 10 年(HR:2.2,95%CI:1.9-2.5;P<.001)的死亡率显著增加相关。LTF 组的中风或死亡风险在 5 年(HR:2.3,95%CI:2.1-2.5;P<.001)和 10 年(HR:2.02,95%CI:1.8-2.3;P<.001)时明显更高。

结论

发现颈动脉血运重建术后 1 年的随访与中风和死亡率无明显相关性。外科医生应向所有接受颈动脉血运重建的患者强调随访的重要性,特别是那些患有多种合并症和术后神经并发症的患者。

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