Hospital of Shimian County, Ya'an, China.
Department of Clinical Epidemiology and Biostatistics, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400016, China.
Prim Care Diabetes. 2022 Dec;16(6):736-744. doi: 10.1016/j.pcd.2022.09.006. Epub 2022 Sep 30.
To assess the impact of the obesity epidemic on type 2 diabetes (T2D), prediabetes and glycometabolic indices in children and adolescents.
We searched four electronic databases (PubMed, Embase, Cochrane and Web of Science). Cross-sectional or cohort studies that reported on obesity and the prevalence of T2D or prediabetes in children and adolescents were reviewed. The study design, sample size and clinical outcomes were extracted from each study. The prevalence of T2D and prediabetes from the studies were pooled using meta-analysis methods.
Meta-analysis of 228184 participants showed that the prevalence of T2D was 1.3% (95% confidence interval (CI), 0.6-2.1%) in obese subjects, which was 13 times that in normal weight subjects (0.1%, 95% CI, 0.01-0.2%). The prevalence of prediabetes in obese subjects was 3 times that in normal subjects at 17.0% (13.0-22.0%) vs. 6.0% (0.01-11.0%). Moreover, BMI was positively correlated with the prevalence of T2D, prediabetes and glycometabolic indices in obese children and adolescents.
The pooled results confirm that obesity in children and adolescents leads to statistically significant increases in the prevalence of T2D and prediabetes and in glycometabolic indicator levels.
评估肥胖症流行对儿童和青少年 2 型糖尿病（T2D）、糖尿病前期和糖代谢指标的影响。
我们检索了四个电子数据库（PubMed、Embase、Cochrane 和 Web of Science）。综述了报告儿童和青少年肥胖与 T2D 或糖尿病前期患病率的横断面或队列研究。从每项研究中提取研究设计、样本量和临床结局。使用荟萃分析方法汇总研究中 T2D 和糖尿病前期的患病率。
对 228184 名参与者的荟萃分析显示，肥胖者 T2D 的患病率为 1.3%（95%置信区间[CI]，0.6-2.1%），是正常体重者的 13 倍（0.1%，95%CI，0.01-0.2%）。肥胖者糖尿病前期的患病率为 17.0%（13.0-22.0%），是正常体重者的 3 倍，为 6.0%（0.01-11.0%）。此外，BMI 与肥胖儿童和青少年的 T2D、糖尿病前期和糖代谢指标的患病率呈正相关。
汇总结果证实，肥胖症会导致儿童和青少年 T2D 和糖尿病前期的患病率以及糖代谢指标水平显著增加。
