Fraile-Martinez Oscar, Alvarez-Mon Miguel A, Garcia-Montero Cielo, Pekarek Leonel, Guijarro Luis G, Lahera Guillermo, Saez Miguel A, Monserrat Jorge, Motogo Domitila, Quintero Javier, Alvarez-Mon Melchor, Ortega Miguel A
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain.
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.
Front Oncol. 2022 Sep 16;12:956923. doi: 10.3389/fonc.2022.956923. eCollection 2022.
In recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, added to the diagnosis of the disease itself, cause an increase in the incidence of depressive disorders. These alterations have important consequences for the patients, reducing their average survival and quality of life, and for these reasons, special emphasis has been placed on developing numerous screening tests and early recognition of depressive symptoms. Despite that cancer and major depressive disorder are complex and heterogeneous entities, they also share many critical pathophysiological mechanisms, aiding to explain this complex relationship from a biological perspective. Moreover, a growing body of evidence is supporting the relevant role of lifestyle habits in the prevention and management of both depression and cancer. Therefore, the present study aims to perform a thorough review of the intricate relationship between depression and cancer, with a special focus on its biological links, clinical management, challenges, and the central role of lifestyle medicine as adjunctive and preventive approaches to improve the quality of life of these patients.
近年来，不同类型癌症的发病率、患者生存率及其患病率都在上升。近年来生存率的提高使患者面临一系列压力因素，如更严格的随访和更积极的治疗方案，再加上疾病本身的诊断，导致抑郁症发病率上升。这些变化对患者有重要影响，降低了他们的平均生存期和生活质量，因此，人们特别重视开展多种筛查测试以及早期识别抑郁症状。尽管癌症和重度抑郁症是复杂且异质性的疾病，但它们也共享许多关键的病理生理机制，有助于从生物学角度解释这种复杂关系。此外，越来越多的证据支持生活方式习惯在抑郁症和癌症的预防与管理中的相关作用。因此，本研究旨在对抑郁症与癌症之间的复杂关系进行全面综述，特别关注其生物学联系、临床管理、挑战以及生活方式医学作为辅助和预防方法在改善这些患者生活质量方面的核心作用。
