Marconcin Priscila, Marques Adilson, Ferrari Gerson, Gouveia Élvio R, Peralta Miguel, Ihle Andreas
Centro Interdisciplinar de Estudo da Performance Humana, Faculdade de Motricidade Humana, Universidade de Lisboa, 1495-751 Lisbon, Portugal.
KinesioLab, Research Unit in Human Movement Analysis, Piaget Institute, 2805-059 Almada, Portugal.
Biology (Basel). 2022 Apr 18;11(4):614. doi: 10.3390/biology11040614.
Cancer patients must deal with several health challenges, including emotional distress and depressive symptoms. This study aimed to evaluate evidence from published systematic reviews and meta-analyses about the efficacy of exercise on depressive symptoms in cancer patients.
We searched for previous meta-analyses of randomised controlled trials on PubMed, Web of Science and Scopus, with data inception to 30 December 2021. Two independent researchers assessed the methodological quality using the Assessment of Multiple Systematic Reviews 2 (AMSTAR2) instrument. Six meta-analyses were integrated. All included middle-aged and older adults. Five presented moderate quality, and one presented low quality.
Overall, a significant reduction in depressive symptoms was observed among the included studies. However, the heterogeneity between studies was high, and high-quality evidence for the efficacy of exercise on depressive symptoms was limited.
Exercise could be a possibility in the treatment of depressive symptoms in cancer patients, especially when supervised and outside the home. The better dose of exercise needs to be clarified. More high-quality evidence is needed to better prescribe exercise to this vulnerable population.
癌症患者必须应对多种健康挑战，包括情绪困扰和抑郁症状。本研究旨在评估已发表的系统评价和荟萃分析中关于运动对癌症患者抑郁症状疗效的证据。
我们在PubMed、科学网和Scopus上检索了截至2021年12月31日关于随机对照试验的先前荟萃分析。两名独立研究人员使用多重系统评价评估2（AMSTAR2）工具评估方法学质量。整合了六项荟萃分析。所有纳入研究均涉及中老年人。五项质量中等，一项质量较低。
总体而言，纳入研究中观察到抑郁症状有显著减轻。然而，研究之间的异质性较高，运动对抑郁症状疗效的高质量证据有限。
运动可能是治疗癌症患者抑郁症状的一种方法，尤其是在有监督且户外进行时。运动的最佳剂量需要进一步明确。需要更多高质量证据，以便更好地为这一脆弱人群开具运动处方。
