Groothuis J R, Rosenberg A A
Am J Dis Child. 1987 Sep;141(9):992-5. doi: 10.1001/archpedi.1987.04460090069028.
To study the effect of oxygen therapy on weight gain in bronchopulmonary dysplasia (BPD), the growth of 22 infants with BPD enrolled in a premature follow-up clinic and home oxygen program was examined retrospectively. Mean gestational age was 28 weeks (range, 26 to 33 weeks) and mean birth weight was 1110 g (range, 680 to 2000 g). After discharge, infants were monitored monthly to maintain transcutaneous oxygen tension over 55 mm Hg and/or pulse oximeter oxygen saturation over 92%. With appropriate home oxygen, all 22 infants grew as well as healthy, full-term infants (mean, 40th percentile; range, tenth to 80th percentile) when ages were corrected for prematurity. Parents discontinued oxygen therapy inappropriately in seven infants, and all seven experienced significant deceleration in weight gain. When home oxygen therapy was resumed, their weight gain improved, but the infants never regained their original percentiles during the study period. The 15 infants who continued home oxygen therapy maintained their original weight percentiles throughout the study period. These data support an important role for home nasal cannula oxygen in promoting weight gain in selected infants with BPD.
为研究氧疗对支气管肺发育不良（BPD）患儿体重增加的影响，我们对22名参加早产随访门诊和家庭氧疗计划的BPD患儿的生长情况进行了回顾性研究。平均胎龄为28周（范围26至33周），平均出生体重为1110克（范围680至2000克）。出院后，每月对婴儿进行监测，以维持经皮氧分压超过55毫米汞柱和/或脉搏血氧饱和度超过92%。在给予适当的家庭氧疗后，所有22名婴儿在矫正早产年龄后，生长情况与健康足月儿相当（平均第40百分位；范围第十至第80百分位）。7名婴儿的家长不恰当地停止了氧疗，这7名婴儿体重增加均显著减缓。当恢复家庭氧疗后，他们的体重增加情况有所改善，但在研究期间这些婴儿的体重百分位再也没有恢复到原来的水平。15名持续接受家庭氧疗的婴儿在整个研究期间维持了其原来的体重百分位。这些数据支持家庭鼻导管给氧在促进部分BPD患儿体重增加方面具有重要作用。
