Rose P G, Herterick E E, Boutselis J G, Moeshberger M, Sachs L
Am J Obstet Gynecol. 1987 Aug;157(2):261-7. doi: 10.1016/s0002-9378(87)80148-5.
Some patients may be predisposed to the development of more than one gynecologic neoplasm. We evaluated 130 cases of synchronous or metachronous tumors among 5967 patients followed up by The Ohio State University Gynecologic Tumor Registry for the past 44 years from 1939 to 1983. Based on primary tumor site and invasive behavior, expected incidences for a specific second malignancy were calculated by the person-years method. A second malignancy of the lower genital tract occurred in patients with cervical, vulvar, and vaginal cancers, 1.6%, 4.3%, and 9.6%, respectively, which supports the theory of multicentric cancer of the lower genital tract. Prior radiation therapy was rarely associated with increased second gynecologic malignancies (two of 41 patients, 4.9%). Four patients had three gynecologic tumors.
一些患者可能易患不止一种妇科肿瘤。我们评估了俄亥俄州立大学妇科肿瘤登记处在1939年至1983年的44年间随访的5967例患者中的130例同步或异时性肿瘤。根据原发肿瘤部位和浸润行为，采用人年法计算特定第二恶性肿瘤的预期发病率。下生殖道的第二恶性肿瘤分别发生在宫颈癌、外阴癌和阴道癌患者中，发生率分别为1.6%、4.3%和9.6%，这支持了下生殖道多中心癌的理论。既往放疗很少与第二妇科恶性肿瘤增加相关（41例患者中有2例，4.9%）。4例患者有三种妇科肿瘤。
