意识障碍持续患者迷走神经磁刺激的初步研究

Preliminary Study of Vagus Nerve Magnetic Modulation in Patients with Prolonged Disorders of Consciousness.

作者信息

Wang Lingling, Wu Qing, Yang Zhenglei, Yang Yuxuan, Luo Yaomin, Cao Yuhong, Wu Li, Xie Yulei, Wang Yinxu

机构信息

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.

Department of Clinical Medicine, North Sichuan Medical College, Nanchong, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2022 Sep 25;18:2171-2179. doi: 10.2147/NDT.S381681. eCollection 2022.

DOI:10.2147/NDT.S381681

PMID:36187561

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9522480/

Abstract

BACKGROUND

The number of patients with prolonged disorders of consciousness (pDOC) is increasing. However, its clinical treatment remains challenging. To date, no studies have reported the effect of vagus nerve modulation (VNM) using repetitive transcranial magnetic stimulation (rTMS) in patients with pDOC. We aimed to evaluate the effect of vagus nerve magnetic modulation (VNMM) on pDOC patients.

METHODS

We performed VNMM in 17 pDOC patients. The Revised Coma Recovery Scale (CRS-R), Glasgow scale (GCS), somatosensory evoked potentials (SEP) and brainstem auditory evoked potentials (BAEP) were assessed before and after treatment.

RESULTS

Both CRS-R and GCS results showed significant improvement in p DOC patients after VNMM treatment. The CRS-R improved from 7.88 ± 2.93 to 11.53 ± 4.94. The GCS score also improved from 7.65 ± 1.9 to 9.18 ± 2.65. The number of BAEP grades I increased from 3 to 5 after treatment. The number of BAEP grades I increased from 3 to 5, grade II increased by 1, and grade III decreased from 4 to 1.

CONCLUSION

This study provides a preliminary indication of the potential of VNMM in the rehabilitation of pDOC patients. It provides the basis for a Phase 2 or Phase 3 study of VNMM in patients with pDOC.

摘要