Mansour Ghanaei Mandana, Asgharnia Maryam, Farokhfar Maryam, Mohammad Asgari Ghalebin Seyed, Rafiei Elahe, Haryalchi Katayoun
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Int J Reprod Biomed. 2022 Aug 8;20(7):591-600. doi: 10.18502/ijrm.v20i7.11561. eCollection 2022 Jul.
Herbal medicine could be effective at treating various illnesses. Hysteroscopy can be an effective method for assessing the uterus in terms of anatomical, physiological and pathological anomalies.
This study aims to evaluate the effect of evening primrose oil (EPO) on cervical preparation in women candidates for hysteroscopy.
This study was a double-blind, randomized controlled clinical trial including 160 women candidates for diagnostic hysteroscopy who were referred to Alzahra hospital from August 2019-March 2020. They were divided into 2 groups. Group A received 100 mg EPO as a soft gel capsule 6 hr before the hysterectomy in the posterior vaginal fornix. Group B received a placebo. After receiving the treatment, primary and secondary outcomes were evaluated in the groups.
The average Hegar size in the EPO group was larger than in the control group (p 0.001 for both). Also, the need for mechanical dilation, the time taken until the first resistance and the time of dilatation completion in the EPO group were significantly less than in the placebo group (p 0.008 for all). There was also greater ease of dilatation in the EPO group. Side effects such as uterine rupture, false passage, cervical rupture, allergic reaction, abdominal pain, nausea, diarrhea, headache and increase of bowel movements were not reported in any cases.
Based on the findings of the present study, EPO is effective for cervical preparation in women undergoing hysteroscopy.
草药可能对治疗各种疾病有效。宫腔镜检查对于评估子宫的解剖、生理和病理异常而言可能是一种有效的方法。
本研究旨在评估月见草油（EPO）对宫腔镜检查女性患者宫颈准备的效果。
本研究为一项双盲、随机对照临床试验，纳入了2019年8月至2020年3月转诊至阿尔扎赫拉医院的160名拟行诊断性宫腔镜检查的女性患者。她们被分为两组。A组在阴道后穹窿进行宫腔镜检查前6小时服用100mg EPO软胶囊。B组服用安慰剂。治疗后，对两组的主要和次要结局进行评估。
EPO组的平均黑加耳氏扩张器大小大于对照组（两者p均<0.001）。此外，EPO组机械扩张的需求、直至出现首次阻力的时间以及扩张完成时间均显著少于安慰剂组（所有p均<0.008）。EPO组的扩张也更轻松。未报告任何子宫破裂、假道形成、宫颈破裂、过敏反应、腹痛、恶心、腹泻、头痛和排便增加等副作用。
基于本研究结果，EPO对接受宫腔镜检查的女性宫颈准备有效。
