Delva E, Camus Y, Paugam C, Parc R, Huguet C, Lienhart A
Anesth Analg. 1987 Sep;66(9):864-8.
The hemodynamic effects of portal triad clamping (PTC) were studied in 48 adult patients scheduled for elective liver resection. Prior to hepatic resection the effects of a short period of PTC (3-5 min) were evaluated in all 48 patients: mean arterial pressure increased 21%, whereas pulmonary capillary wedge pressure and cardiac index decreased 10 and 17%, respectively. Systemic vascular resistance increased 48%. In 34 patients a liver resection was performed during PTC and hemodynamic measurements were repeated throughout the duration of liver ischemia, which ranged from 14 to 68 min. Hemodynamic changes occurred in the first 3 min and persisted thereafter. After releasing the clamp, hemodynamic parameters returned to initial values in 3 min. These results confirm that PTC does not induce the cardiovascular collapse in humans that it does in common laboratory animals and demonstrate that humans tolerate PTC for periods up to 1 hr.
对48例计划择期肝切除术的成年患者研究了肝门三联阻断（PTC）的血流动力学效应。在肝切除术前，对所有48例患者评估了短时间PTC（3 - 5分钟）的效应：平均动脉压升高21%，而肺毛细血管楔压和心脏指数分别降低10%和17%。全身血管阻力增加48%。34例患者在PTC期间进行了肝切除术，并在整个肝缺血期间（14至68分钟）重复进行血流动力学测量。血流动力学变化在最初3分钟出现并持续至此后。松开阻断钳后，血流动力学参数在3分钟内恢复至初始值。这些结果证实，PTC在人类中不会像在常见实验动物中那样诱发心血管虚脱，并表明人类能够耐受长达1小时的PTC。
