Institute of Medical Sciences, University of Aberdeen, Ashgrove Road West, Foresterhill Aberdeen AB25 2ZD, UK.
Department of Microbiology, University of Helsinki, P.O.Box 56, Viikki Biocenter, Viikinkaari 9, 00014, Finland.
Chem Commun (Camb). 2022 Oct 27;58(86):12054-12057. doi: 10.1039/d2cc01799g.
Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that the prenyl-D-Arg-containing autumnalamide A is a member of the cyanobactin family. Biochemical assays demonstrate that the AutF prenyltransferase targets the guanidinium moiety in arginine and homoarginine and is a useful tool for biotechnological applications.
蓝细菌素是线性和环状的翻译后修饰肽。在这里，我们表明含有prenyl-D-Arg 的秋酰胺 A 是蓝细菌素家族的一员。生化测定表明 AutF prenyltransferase 靶向精氨酸和同型精氨酸的胍基部分，是生物技术应用的有用工具。
