School of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Jingyue National High-Tech Industrial Development Zone, Changchun, Jilin, China.
Department of Encephalology, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
Medicine (Baltimore). 2022 Sep 23;101(38):e30606. doi: 10.1097/MD.0000000000030606.
The objectives of this study were to determine the preventive effects of statins on stroke.
The published randomized controlled trials of statins for stroke prevention were searched from PubMed, EMBASE, Cochrane Library, and China Journal databases. We performed the meta-analysis via calculating the odds ratio (OR) and 95% confidence interval (CI) to study the mortality rate, incidence, and recurrence rate of patients with stroke in the prevention group and the control group. Chi-square-based Q test and I2 statistics were performed to test the potential heterogeneity; we conducted the sensitivity analysis to assess the stability of our analysis. Moreover, we performed the Begg and Egger tests to assess the publication bias.
Nine studies were included to perform meta-analysis, which included 15,497 patients (prevention group [n = 4114]; control group [n = 11383]). We found that the statins were not associated with the patients with stroke in mortality rate (OR = 1.00, 95% CI [0.82, 1.23]) and incidence (OR = 0.94, 95% CI [0.46, 1.92]) between the 2 groups. However, there was a significant differences in recurrence rate between the 2 groups (OR = 0.31, 95% CI [0.19, 0.51]).
Our findings indicated that the statins were associated with the patients with stroke in recurrence rate, but there was no significant correlation with the mortality and morbidity of patients with stroke.
本研究旨在确定他汀类药物对卒中的预防作用。
从 PubMed、EMBASE、Cochrane Library 和中国期刊全文数据库中检索他汀类药物预防卒中的已发表随机对照试验。通过计算比值比（OR）和 95%置信区间（CI），我们对预防组和对照组患者的卒中死亡率、发生率和复发率进行了荟萃分析。采用基于卡方的 Q 检验和 I2 统计量检验潜在的异质性；我们进行敏感性分析以评估我们分析的稳定性。此外，我们进行了 Begg 和 Egger 检验以评估发表偏倚。
纳入 9 项研究进行荟萃分析，共纳入 15497 例患者（预防组[n=4114]；对照组[n=11383]）。我们发现他汀类药物与卒中患者的死亡率（OR=1.00，95%CI[0.82，1.23]）和发生率（OR=0.94，95%CI[0.46，1.92]）均无相关性。然而，两组患者的复发率存在显著差异（OR=0.31，95%CI[0.19，0.51]）。
我们的研究结果表明，他汀类药物与卒中患者的复发率有关，但与卒中患者的死亡率和发病率无显著相关性。
