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Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.用于成年人心血管疾病一级预防的他汀类药物:美国预防服务工作组的更新证据报告和系统评价。
JAMA. 2022 Aug 23;328(8):754-771. doi: 10.1001/jama.2022.12138.
4
Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement.他汀类药物用于成年人的心血管疾病一级预防:美国预防服务工作组推荐声明。
JAMA. 2022 Aug 23;328(8):746-753. doi: 10.1001/jama.2022.13044.
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Neuroepidemiology. 2022;56(4):240-249. doi: 10.1159/000525672. Epub 2022 Jun 26.
6
Antihypertensives and Statin Therapy for Primary Stroke Prevention: A Secondary Analysis of the HOPE-3 Trial.抗高血压药物和他汀类药物治疗用于首发脑卒中预防:HOPE-3 试验的二次分析。
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他汀类药物领域导航:卒中预防策略的全面综述

Navigating the Statin Landscape: A Comprehensive Review of Stroke Prevention Strategies.

作者信息

Deolikar Vinit, Raut Sarang S, Toshniwal Saket, Kumar Sunil, Acharya Sourya

机构信息

Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.

General Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.

出版信息

Cureus. 2024 Feb 4;16(2):e53555. doi: 10.7759/cureus.53555. eCollection 2024 Feb.

DOI:10.7759/cureus.53555
PMID:38445155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10913842/
Abstract

This review provides a comprehensive exploration of the intricate relationship between statins and stroke prevention within the broader context of cardiovascular health. Delving into the mechanisms of statins, we elucidate their multifaceted contributions, ranging from cholesterol reduction to pleiotropic effects on the vascular system. Through a meticulous analysis of clinical trials, observational studies, and mechanistic investigations, we underscore the pivotal role of statins as integral components in the arsenal against strokes and associated cardiovascular events. The implications extend beyond statins as standalone interventions, emphasizing the potential for synergistic integration into broader stroke prevention strategies. Tailoring interventions to individual patient profiles and understanding the interplay with lifestyle modifications and other pharmacological approaches present opportunities for optimizing efficacy. Recommendations for future research advocate for continued exploration into the long-term effects of statin therapy, novel intervention combinations, and refined predictive models for personalized risk assessment. On a practical level, enhancing patient education, fostering interdisciplinary collaboration, and addressing barriers to medication adherence emerge as crucial aspects for real-world impact. In navigating this evolving landscape, the insights derived from this review contribute to informed decision-making and advancements in preventive cardiovascular medicine.

摘要

本综述在心血管健康这一更广泛背景下,全面探讨了他汀类药物与中风预防之间的复杂关系。深入研究他汀类药物的作用机制后,我们阐明了它们的多方面贡献,从降低胆固醇到对血管系统的多效性作用。通过对临床试验、观察性研究和机制研究的细致分析,我们强调了他汀类药物作为预防中风及相关心血管事件的重要组成部分所起的关键作用。其影响不仅限于他汀类药物作为单一干预措施,还强调了将其协同整合到更广泛的中风预防策略中的潜力。根据个体患者情况定制干预措施,并了解其与生活方式改变及其他药物治疗方法的相互作用,为优化疗效提供了机会。对未来研究的建议主张持续探索他汀类药物治疗的长期效果、新型干预组合以及用于个性化风险评估的改进预测模型。在实际层面,加强患者教育、促进跨学科合作以及解决药物依从性障碍是产生实际影响的关键方面。在应对这一不断变化的领域时,本综述得出的见解有助于在预防性心血管医学中做出明智决策并取得进展。