Askin Lutfu, Askin Husna Sengul, Tanrıverdi Okan, Ozyildiz Ali Gokhan, Duman Hakan
Department of Cardiology, Adiyaman Training and Research Hospital, Adiyaman, Turkiye.
Department of Infectious disease, Adiyaman Training and Research Hospital, Adiyaman, Turkiye.
North Clin Istanb. 2022 May 11;9(3):290-294. doi: 10.14744/nci.2021.33427. eCollection 2022.
Apelin is a G protein-linked receptor endogenous ligand, synthesized as a 77-amino acid pre-propeptide. Increased expression of apelin is present in many cardiovascular (CV) tissues, including cardiomyocytes. It is a peripheral vasodilator and one of the most potent stimulants of ventricular contraction. Apelin may be a valuable therapeutic for both blood pressure regulation and myocardial performance. More information is needed for the CV pathophysiology of apelin. We will discuss the importance of apelin level in CV diseases in this review.
阿片肽是一种与G蛋白偶联的受体内源性配体，作为一种含77个氨基酸的前原肽合成。阿片肽在包括心肌细胞在内的许多心血管（CV）组织中表达增加。它是一种外周血管扩张剂，也是最有效的心室收缩刺激剂之一。阿片肽可能是调节血压和心肌功能的一种有价值的治疗手段。关于阿片肽的心血管病理生理学还需要更多信息。在这篇综述中，我们将讨论阿片肽水平在心血管疾病中的重要性。
