National Centre for Infectious Diseases, Singapore, Singapore.
Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore.
J Infect Dis. 2023 Apr 18;227(8):1002-1006. doi: 10.1093/infdis/jiac409.
Serological testing of Singaporeans who received childhood smallpox vaccination found anti-vaccinia IgG binding and neutralizing activity indicating long-term humoral immunity. There was correlation between IgG and neutralizing titers indicating IgG could be used as a surrogate marker for humoral immunity. In 2019, Singapore experienced a case of imported monkeypox. As with smallpox, disease can be prevented through vaccination, which was mandatory for Singaporean infants until 1981. However, the degree of residual immunity in older vaccinated Singaporeans remains unknown. Sera from individuals born 1946-1984 were therefore tested and those born prior to 1981 were found to have higher anti-vaccinia IgG and neutralizing activity titers. This suggests that protective humoral immunity remains, which could reduce disease severity in an orthopoxvirus outbreak. Correlation between IgG and neutralizing titers was observed indicating that serology could be used as a surrogate marker for immunity.
对接受过小儿麻痹症疫苗接种的新加坡人的血清学检测发现，抗天花 IgG 结合和中和活性表明长期体液免疫。IgG 和中和效价之间存在相关性，表明 IgG 可用作体液免疫的替代标志物。2019 年，新加坡发生了一起输入性猴痘病例。与天花一样，疾病可以通过疫苗接种来预防，新加坡婴儿在 1981 年之前必须接种疫苗。然而，年龄较大的已接种疫苗的新加坡人仍存在多少残余免疫力尚不清楚。因此，对 1946 年至 1984 年出生的个体的血清进行了检测，发现 1981 年之前出生的个体具有更高的抗天花 IgG 和中和活性滴度。这表明保护性体液免疫仍然存在，这可以降低正痘病毒爆发时的疾病严重程度。观察到 IgG 和中和效价之间的相关性，表明血清学可用作免疫的替代标志物。
