Key Laboratory of Public Health Safety of Hebei Province, School of Public Health, Hebei University, Baoding, China.
Department of Gynecology, Baoding Maternal and Child Health Hospital, Baoding, China.
Diabetes Obes Metab. 2023 Feb;25(2):342-353. doi: 10.1111/dom.14886. Epub 2022 Oct 24.
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, affecting 14% of pregnancies worldwide, and the prevention of pathological hyperglycaemia during pregnancy is meaningful for global public health. The role of iron supplementation in the progression of GDM has been of significant interest in recent years. Iron is a micronutrient that is vital during pregnancy; however, given the toxic properties of excess iron, it is probable that prophylactic iron supplementation will increase the risk of adverse pregnancy outcomes, including GDM. It is critical to clarify the effect of iron supplementation on the risk of GDM. Therefore, in this review, we comprehensively assess the role of iron in pregnancy. This review aimed to analyse the necessity of iron supplementation and maintenance of iron homeostasis during pregnancy, particularly reviewing the role and function of iron in beta cells and examining the mechanisms of excess iron contributing to the pathogenesis of GDM. Moreover, we aimed to discuss the association of haemoglobin and ferritin with GDM and identify priority areas for research.
妊娠期糖尿病（GDM）是一种常见的妊娠并发症，影响全球 14%的妊娠，预防妊娠期间病理性高血糖对全球公共健康具有重要意义。近年来，铁补充剂在 GDM 进展中的作用引起了广泛关注。铁是妊娠期间必需的微量元素；然而，由于过量铁具有毒性，预防性铁补充剂可能会增加包括 GDM 在内的不良妊娠结局的风险。阐明铁补充剂对 GDM 风险的影响至关重要。因此，在本次综述中，我们全面评估了铁在妊娠中的作用。本综述旨在分析妊娠期间铁补充和铁平衡维持的必要性，特别分析铁在β细胞中的作用和功能，并探讨过量铁导致 GDM 发病机制的机制。此外，我们还旨在讨论血红蛋白和铁蛋白与 GDM 的关系，并确定研究的重点领域。
