Polich J, Bloom F E
Alcohol. 1987 Jul-Aug;4(4):301-5. doi: 10.1016/0741-8329(87)90027-9.
The P300 event-related brain potential (ERP) was obtained from 24 pairs of undergraduate male subjects. One member of each pair reported having a father who was alcoholic (FH+), the other reported no alcoholic family member (FH-). Pairs were matched on height, weight, academic performance, and personal drinking history. Three auditory task situations were employed which manipulated stimulus discrimination difficulty. All tasks employed 20% target and 80% standard tones randomly presented with the subjects required to move their index finger whenever a target tone was detected. No differences in P300 amplitude or latency were obtained between the groups. FH+ subjects tended to demonstrate decreased amplitudes with increased amounts of reported alcohol consumption but only for the most difficult task. The results of the present study suggest that the relationship between the P300 and the heritability for alcoholism is not yet clear and may be modulated by differences in task requirements, subject populations, and personal drinking history.
从24对本科男性受试者中获取了P300事件相关脑电位（ERP）。每对中的一名成员报告其父亲为酗酒者（FH+），另一名报告没有酗酒家庭成员（FH-）。这些对子在身高、体重、学业成绩和个人饮酒史方面进行了匹配。采用了三种听觉任务情境，这些情境操纵了刺激辨别难度。所有任务都使用了20%的目标音和80%的标准音，随机呈现，要求受试者每当检测到目标音时就移动食指。两组之间在P300波幅或潜伏期方面没有差异。FH+受试者往往随着报告的饮酒量增加而波幅降低，但仅在最困难的任务中如此。本研究结果表明，P300与酒精中毒遗传度之间的关系尚不清楚，可能会受到任务要求、受试者群体和个人饮酒史差异的调节。
