Dimery I W, Jones L A, Verjan R P, Raymond A K, Goepfert H, Hong W K
Arch Otolaryngol Head Neck Surg. 1987 Oct;113(10):1082-5. doi: 10.1001/archotol.1987.01860100060022.
To access for possible hormone dependence, 19 samples of normal salivary gland tissue and 14 samples of salivary gland carcinoma were quantitatively analyzed for estrogen receptor (ER) content. A receptor protein content of greater than or equal to 1 fmol/mg of cytosol protein was considered positive. Ten (77%) of 13 histologically normal samples, and four (80%) of five tumor samples obtained from male patients contained ER by this criterion, as did five (83%) of six normal samples and eight (88%) of nine tumor samples obtained from female patients. Mean ER concentrations plus or minus SE in male-derived samples were 2.02 +/- .42 fmol/mg of cytosol protein for normal tissue and 4.35 +/- 1.5 fmol/mg of cytosol protein for tumor tissue; mean ER concentrations in female-derived samples were 3.48 +/- 1.1 fmol/mg of cytosol protein for normal tissue and 12.64 +/- 6.4 fmol/mg of cytosol protein for tumor tissue. Four of eight tumors in women had levels considered to be "hormonally dependent" in breast carcinoma. These findings indicate that salivary gland carcinomas may be hormone-dependent.
为确定是否存在激素依赖性，对19份正常唾液腺组织样本和14份唾液腺癌样本的雌激素受体（ER）含量进行了定量分析。以每毫克胞浆蛋白中受体蛋白含量大于或等于1飞摩尔为阳性标准。按照这一标准，13份组织学正常的男性样本中有10份（77%）、5份男性肿瘤样本中有4份（80%）含有ER；6份正常女性样本中有5份（83%）、9份女性肿瘤样本中有8份（88%）含有ER。男性来源样本中，正常组织的平均ER浓度±标准误为每毫克胞浆蛋白2.02±0.42飞摩尔，肿瘤组织为每毫克胞浆蛋白4.35±1.5飞摩尔；女性来源样本中，正常组织的平均ER浓度为每毫克胞浆蛋白3.48±1.1飞摩尔，肿瘤组织为每毫克胞浆蛋白12.64±6.4飞摩尔。女性的8例肿瘤中有4例的水平在乳腺癌中被认为是“激素依赖性”的。这些发现表明唾液腺癌可能是激素依赖性的。
