建立一个综合的血清学监测平台，为公共卫生干预措施提供信息：血清生物标志物专家会议的见解。
Building an integrated serosurveillance platform to inform public health interventions: Insights from an experts' meeting on serum biomarkers.
机构信息
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Mérieux Foundation USA, Washington, District of Columbia, United States of America.
出版信息
PLoS Negl Trop Dis. 2022 Oct 6;16(10):e0010657. doi: 10.1371/journal.pntd.0010657. eCollection 2022 Oct.
Abstract
The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public health program design and response to infectious threats. In July 2018, 70 scientists from 16 countries met to perform a landscape analysis of approaches that support an integrated serosurveillance platform, including the consideration of issues for successful implementation. Here, we summarize the group's insights and proposed roadmap for implementation, including objectives, technical requirements, ethical issues, logistical considerations, and monitoring and evaluation.
摘要
使用生物标志物来测量血清中的免疫反应对于了解人群对人类病原体的暴露和易感性至关重要。样本采集、多重检测和计算模型的进步正在将血清监测转变为公共卫生计划设计和应对传染病威胁的有力工具。2018 年 7 月，来自 16 个国家的 70 名科学家开会对支持综合血清监测平台的方法进行了景观分析，包括对成功实施的问题进行了审议。在这里，我们总结了小组的见解和实施路线图，包括目标、技术要求、道德问题、后勤考虑因素以及监测和评估。
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