Swapna Y V, Mathew C T, K Thomas Jijimon
Electronic Materials Research Laboratory, Department of Physics, Mar Ivanios College, Thiruvananthapuram, 695015, Kerala, India.
Electronic Materials Research Laboratory, Department of Physics, Mar Ivanios College, Thiruvananthapuram, 695015, Kerala, India.
J Mech Behav Biomed Mater. 2022 Dec;136:105488. doi: 10.1016/j.jmbbm.2022.105488. Epub 2022 Sep 29.
Enhancing the mechanical properties of biocompatible hydroxyapatite is one of the major challenges in the fabrication of bone implants. In this work, phase pure samples of nano-hydroxyapatite with an average crystallite size of 22 nm, were synthesized by a modified single-step combustion technique. The samples were sintered by a novel resistive coupled microwave sintering technique to 98.4% of theoretical density at 1030 °C for a soaking duration of 20 min. The new method yielded pellets with an average grain size of 0.12 ± 0.01 μm, that showed an improved Vickers microhardness of 7.1 GPa, enhanced young's modulus of 110.51 ± 1.8 GPa, and better compressive strength of 172 ± 10 MPa compared to those pellets sintered via conventional resistive heating. The sintered samples showed better cell viability, cell adhesion, proliferation, differentiation, and osteogenic potential. The enhanced mechanical properties achieved by resistive coupled microwave sintering without compromising the biological properties is a remarkable result that can effectively be used in the fabrication of high-quality bone substitutes.
提高生物相容性羟基磷灰石的力学性能是骨植入物制造中的主要挑战之一。在这项工作中，通过改进的单步燃烧技术合成了平均微晶尺寸为22nm的纯相纳米羟基磷灰石样品。采用新型电阻耦合微波烧结技术在1030℃下将样品烧结至理论密度的98.4%，保温20分钟。与通过传统电阻加热烧结的颗粒相比，新方法制备的颗粒平均晶粒尺寸为0.12±0.01μm，维氏显微硬度提高到7.1GPa，杨氏模量提高到110.51±1.8GPa，抗压强度提高到172±10MPa。烧结后的样品表现出更好的细胞活力、细胞粘附、增殖、分化和成骨潜力。通过电阻耦合微波烧结实现的机械性能增强而不损害生物学性能是一个显著的结果，可有效地用于制造高质量的骨替代物。
