Swapna Y V, Mathew C T, Thomas Jijimon K
Electronic Materials Research Laboratory, Department of Physics, Mar Ivanios College, Thiruvananthapuram, 695015, Kerala, India.
Electronic Materials Research Laboratory, Department of Physics, Mar Ivanios College, Thiruvananthapuram, 695015, Kerala, India.
J Mech Behav Biomed Mater. 2023 May;141:105772. doi: 10.1016/j.jmbbm.2023.105772. Epub 2023 Mar 10.
Tailoring the mechanical properties of bioceramics plays a crucial role in the fabrication of hard tissue substitutes. In this work, phase pure nanostructured hydroxyapatite and titania were synthesized using a single-step combustion technique. To study the influence of titania in the mechanical properties of hydroxyapatite, hydroxyapatite/titania (TiO-0%, 10%, 20%, and 30%) nanocomposites were prepared. The sample containing 20% titania showed maximum sinterability and was analysed in detail. The samples were sintered by a novel resistive coupled microwave sintering to 98.9% of the theoretical density at 1020 °C for a soaking duration of 20 min. A substantial reduction in sintering temperature of ∼165 °C and a significantly low soaking duration were observed in the samples sintered using the new technique and it yielded pellets with reduced grain size compared to the samples sintered via conventional resistive heating. They have shown better microhardness of 7.7 GPa, enhanced compressive strength of 194.9 MPa, and improved elastic modulus of 136.2 GPa without compromising the cell viability, cell adhesion, differentiation, proliferation, and biomineralization. The results indicate that by varying the titania content in hydroxyapatite and by adopting a suitable low-temperature sintering strategy like resistive coupled microwave sintering, one can tailor the mechanical properties of bone implants.
调整生物陶瓷的机械性能在硬组织替代物的制造中起着至关重要的作用。在这项工作中，采用单步燃烧技术合成了相纯的纳米结构羟基磷灰石和二氧化钛。为了研究二氧化钛对羟基磷灰石机械性能的影响，制备了羟基磷灰石/二氧化钛（TiO-0%、10%、20%和30%）纳米复合材料。含有20%二氧化钛的样品表现出最大的烧结性，并进行了详细分析。通过新型电阻耦合微波烧结在1020℃下保温20分钟，将样品烧结至理论密度的98.9%。与通过传统电阻加热烧结的样品相比，采用新技术烧结的样品烧结温度大幅降低约165℃，保温时间显著缩短，且得到的颗粒晶粒尺寸更小。它们表现出更好的显微硬度7.7 GPa、更高的抗压强度194.9 MPa和改进的弹性模量136.2 GPa，同时不影响细胞活力、细胞粘附、分化、增殖和生物矿化。结果表明，通过改变羟基磷灰石中二氧化钛的含量并采用合适的低温烧结策略，如电阻耦合微波烧结，可以调整骨植入物的机械性能。
