乙醇与血小板细胞内游离钙浓度
Ethanol and platelet intracellular free calcium concentrations.
作者信息
Lees K R, Barr S M, Butters L, Rubin P C
出版信息
Br J Clin Pharmacol. 1987 Jul;24(1):114-6. doi: 10.1111/j.1365-2125.1987.tb03147.x.
The effect of 0.8 g kg-1 absolute ethanol orally on platelet intracellular free calcium was assessed in a random order study in 24 normotensive subjects with an isocaloric control. Platelet calcium was measured 90 min and 12 h after treatment by the Quin 2 method. The study had 90% power of detecting a 16.5% change. After 90 min, breath ethanol was 37 +/- 9 micrograms 100 ml-1, blood pressure was unchanged and heart rate rose slightly. Platelet calcium was unchanged by ethanol after 90 min or 12 h.
在一项随机序贯研究中，对24名血压正常的受试者给予0.8 g/kg的口服无水乙醇，并设置等热量对照，评估其对血小板细胞内游离钙的影响。采用喹啉2法在治疗后90分钟和12小时测量血小板钙含量。该研究有90%的把握检测到16.5%的变化。90分钟后，呼气乙醇含量为37±9微克/100毫升，血压未变，心率略有上升。90分钟或12小时后，乙醇对血小板钙含量无影响。
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