Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, PO Box 5000, 90014, Oulu, Finland.
Forensic Medicine Unit, Finnish Institute for Health and Welfare (THL), Oulu, Finland.
Sci Rep. 2022 Oct 6;12(1):16771. doi: 10.1038/s41598-022-20250-3.
Alcohol is known to have an immediate effect on cardiac rhythm, and previous studies have found that a notable proportion of sudden cardiac deaths (SCD) occur after alcohol intake. The objective of the present study was to investigate the association between the timing of alcohol intake and SCD. Our study population is drawn from the Fingesture study, which includes 5869 consecutive SCD cases from Northern Finland who underwent medicolegal autopsy 1998-2017. Toxicological analysis was performed if there was any suspicion of toxic exposure, or if there was no obvious immediate cause of SCD at autopsy. We found that 1563 (27%) of all SCD victims had alcohol in blood or urine at autopsy (mean age (61 ± 10 years, 88% male). Eighty-six percent of alcohol-related SCD victims had higher urine alcohol concentration than blood alcohol concentration, referring to the late-stage inebriation. These results suggest that the majority of alcohol-related SCDs occur at the late stage of inebriation.
酒精会对心律产生即时影响，先前的研究发现，相当一部分心源性猝死（SCD）发生在饮酒之后。本研究旨在探讨饮酒时间与 SCD 之间的关系。我们的研究人群来自芬兰北部的 Fingesture 研究，该研究纳入了 1998-2017 年间接受法医尸检的 5869 例连续 SCD 病例。如果存在中毒暴露的任何可疑迹象，或者尸检时没有明显的 SCD 直接原因，则进行毒理学分析。我们发现，所有 SCD 受害者中有 1563 例（27%）在尸检时血液或尿液中有酒精（平均年龄（61±10 岁，88%为男性））。86%的与酒精相关的 SCD 受害者尿液中的酒精浓度高于血液中的酒精浓度，这表明他们处于醉酒晚期。这些结果表明，大多数与酒精相关的 SCD 发生在醉酒晚期。
