Li Xinyi, Wang Mengya, Liu Shimin, Chen Xiaodong, Qiao Yu, Yang Xiaojun, Yao Junhu, Wu Shengru
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Department of Medicine, Karolinska Institutet, Solna, Stockholm 17165, Sweden.
Anim Nutr. 2022 Jul 22;11:142-151. doi: 10.1016/j.aninu.2022.07.002. eCollection 2022 Dec.
The use of antibiotics in animal feeding has been banned in many countries because of increasing concerns about the development of bacterial resistance to antibiotics and potential issues on food safety. Searching for antibiotic substitutes is essential. Applying transgenerational epigenetic technology to animal production could be an alternative. Some environmental changes can be transferred to memory-like responses in the offspring through epigenetic mechanisms without changing the DNA sequence. In this paper, we reviewed those nutrients and non-nutritional additives that have transgenerational epigenetic effects, including some amino acids, vitamins, and polysaccharides. The paternal transgenerational nutritional epigenetic regulation was particularly focused on mechanism of the substantial contribution of male stud animals to the animal industries. We illustrated the effects of paternal transgenerational epigenetics on the metabolism and immunity in farming animals and proposed strategies to modulate male breeding livestock or poultry.
由于对细菌对抗生素耐药性的发展以及食品安全潜在问题的日益担忧，许多国家已禁止在动物饲养中使用抗生素。寻找抗生素替代品至关重要。将跨代表观遗传技术应用于动物生产可能是一种选择。一些环境变化可通过表观遗传机制传递给后代类似记忆的反应，而不改变DNA序列。在本文中，我们综述了具有跨代表观遗传效应的营养物质和非营养添加剂，包括一些氨基酸、维生素和多糖。父系跨代营养表观遗传调控特别关注雄性种畜对畜牧业的重大贡献机制。我们阐述了父系跨代表观遗传学对养殖动物代谢和免疫的影响，并提出了调控雄性种畜禽的策略。
