• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

模拟生命早期阴道微生物群从母亲到婴儿的转移。

Modeling transfer of vaginal microbiota from mother to infant in early life.

机构信息

Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen University Hospital Gentofte, Hellerup, Denmark.

出版信息

Elife. 2021 Jan 15;10:e57051. doi: 10.7554/eLife.57051.

DOI:10.7554/eLife.57051
PMID:33448927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7810462/
Abstract

Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota's role in seeding the child's microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother-child dyads from the COPSAC cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children's fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.

摘要

早期的微生物群与慢性炎症性疾病的发展有关。据推测，母体阴道微生物群是一个重要的初始定植源，因此可能对疾病风险有终身影响。为了了解母体阴道微生物群在为儿童定植微生物群方面的作用以及分娩方式依赖性传播的程度，我们研究了来自 COPSAC 队列的 665 对母婴对子。在妊娠晚期对母体阴道微生物群进行了两次评估，并与儿童的粪便（1 周、1 个月和 1 岁时）和气道微生物群（1 周、1 个月和 3 个月时）进行了比较。基于加权转移比 (WTR) 的概念，我们已经确定了细菌目，其中 WTR 显示出表明从母体阴道微生物组持续或短暂转移的模式，以及在不依赖分娩方式的后期时间点共享的目，这表明存在共同的储库。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/a628b3271489/elife-57051-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/5eeb44e72e52/elife-57051-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/4bb6c92626c2/elife-57051-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/1fe482245e37/elife-57051-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/14551a40e206/elife-57051-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/538424eb0b11/elife-57051-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/cff56a1a7455/elife-57051-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/e22f91f2e5d6/elife-57051-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/915bc7ccedba/elife-57051-fig4-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/451a1c4386b9/elife-57051-fig4-figsupp4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/3e65e98a3822/elife-57051-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/a628b3271489/elife-57051-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/5eeb44e72e52/elife-57051-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/4bb6c92626c2/elife-57051-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/1fe482245e37/elife-57051-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/14551a40e206/elife-57051-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/538424eb0b11/elife-57051-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/cff56a1a7455/elife-57051-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/e22f91f2e5d6/elife-57051-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/915bc7ccedba/elife-57051-fig4-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/451a1c4386b9/elife-57051-fig4-figsupp4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/3e65e98a3822/elife-57051-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257f/7810462/a628b3271489/elife-57051-fig5-figsupp1.jpg

相似文献

1
Modeling transfer of vaginal microbiota from mother to infant in early life.模拟生命早期阴道微生物群从母亲到婴儿的转移。
Elife. 2021 Jan 15;10:e57051. doi: 10.7554/eLife.57051.
2
Birth Mode Does Not Determine the Presence of Shared Bacterial Strains between the Maternal Vaginal Microbiome and the Infant Stool Microbiome.分娩方式并不会决定母婴阴道微生物群和婴儿粪便微生物群之间的细菌菌株共享。
Microbiol Spectr. 2023 Aug 17;11(4):e0061423. doi: 10.1128/spectrum.00614-23. Epub 2023 Jun 20.
3
Does the maternal vaginal microbiota play a role in seeding the microbiota of neonatal gut and nose?产妇阴道微生物群在为新生儿肠道和鼻腔定植微生物群中起作用吗？
Benef Microbes. 2017 Oct 13;8(5):763-778. doi: 10.3920/BM2017.0064. Epub 2017 Oct 12.
4
Does vaginal delivery mitigate or strengthen the intergenerational association of overweight and obesity? Findings from the Boston Birth Cohort.阴道分娩会减轻还是强化超重与肥胖的代际关联？来自波士顿出生队列的研究结果。
Int J Obes (Lond). 2017 Apr;41(4):497-501. doi: 10.1038/ijo.2016.219. Epub 2016 Nov 30.
5
Maternal Bacterial Engraftment in Multiple Body Sites of Cesarean Section Born Neonates after Vaginal Seeding-a Randomized Controlled Trial.剖宫产儿阴道定植后多个部位的母婴细菌定植：一项随机对照试验。
mBio. 2023 Jun 27;14(3):e0049123. doi: 10.1128/mbio.00491-23. Epub 2023 Apr 19.
6
Gut microbiota transfer evidence from mother to newborn.肠道微生物群将母体的证据转移给新生儿。
Eur J Pediatr. 2024 Feb;183(2):749-757. doi: 10.1007/s00431-023-05341-1. Epub 2023 Nov 21.
7
Perinatal Antibiotic Exposure Affects the Transmission between Maternal and Neonatal Microbiota and Is Associated with Early-Onset Sepsis.围产期抗生素暴露会影响母婴微生物群之间的传播，并与早发性败血症有关。
mSphere. 2020 Feb 19;5(1):e00984-19. doi: 10.1128/mSphere.00984-19.
8
Association of prevalent vaginal microbiome of mother with occurrence of type I diabetes in child.母亲阴道微生物组的流行与儿童 I 型糖尿病的发生有关。
Sci Rep. 2019 Jan 30;9(1):959. doi: 10.1038/s41598-018-37467-w.
9
Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study.剖宫产儿的母体粪便微生物移植可快速恢复正常肠道微生物发育：概念验证研究。
Cell. 2020 Oct 15;183(2):324-334.e5. doi: 10.1016/j.cell.2020.08.047. Epub 2020 Oct 1.
10
Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites.母婴微生物群传播和多个身体部位的婴儿微生物群发育。
Cell Host Microbe. 2023 Mar 8;31(3):447-460.e6. doi: 10.1016/j.chom.2023.01.018.

引用本文的文献

1
Adverse pregnancy outcomes in women with type 1 diabetes are associated with multiple alterations in the vaginal microbiome.1型糖尿病女性的不良妊娠结局与阴道微生物群的多种改变有关。
Diabetologia. 2025 Aug 7. doi: 10.1007/s00125-025-06509-0.
2
The Effect of Probiotics on Health in Pregnancy and Infants: A Randomized, Double-Blind, Placebo-Controlled Trial.益生菌对母婴健康的影响：一项随机、双盲、安慰剂对照试验
Nutrients. 2025 May 28;17(11):1825. doi: 10.3390/nu17111825.
3
Composition of the fecal, vaginal and colostrum microbiotas of dams at parturition and their relationship with neonatal outcomes in dogs.

本文引用的文献

1
Ecological succession in the vaginal microbiota during pregnancy and birth.阴道微生物群在妊娠和分娩期间的生态演替。
ISME J. 2020 Sep;14(9):2325-2335. doi: 10.1038/s41396-020-0686-3. Epub 2020 Jun 2.
2
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.剖宫产出生婴儿的发育不良微生物组和机会性病原体定植。
Nature. 2019 Oct;574(7776):117-121. doi: 10.1038/s41586-019-1560-1. Epub 2019 Sep 18.
3
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2.使用QIIME 2进行可重复、交互式、可扩展和可延伸的微生物组数据科学研究。
分娩时母犬粪便、阴道和初乳微生物群的组成及其与犬新生儿结局的关系。
Anim Microbiome. 2025 Mar 6;7(1):23. doi: 10.1186/s42523-025-00384-1.
4
Vaginal Seeding: Is There Any Positive Effect in Canine C-Sections?阴道接种：对犬类剖腹产有任何积极影响吗？
Animals (Basel). 2025 Feb 2;15(3):416. doi: 10.3390/ani15030416.
5
A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers.预防儿童白血病的直觉：针对父母和照顾者的微生物群靶向建议。
Front Public Health. 2025 Jan 13;12:1445113. doi: 10.3389/fpubh.2024.1445113. eCollection 2024.
6
The Association of Neonatal Gut Microbiota Community State Types with Birth Weight.新生儿肠道微生物群群落状态类型与出生体重的关联
Children (Basel). 2024 Jun 25;11(7):770. doi: 10.3390/children11070770.
7
Microbiota and Gut-Liver Axis: An Unbreakable Bond?微生物群和肠-肝轴：牢不可破的联系？
Curr Microbiol. 2024 May 28;81(7):193. doi: 10.1007/s00284-024-03694-w.
8
Vertical Metabolome Transfer from Mother to Child: An Explainable Machine Learning Method for Detecting Metabolomic Heritability.从母亲到孩子的垂直代谢组转移：一种用于检测代谢组遗传力的可解释机器学习方法。
Metabolites. 2024 Feb 24;14(3):136. doi: 10.3390/metabo14030136.
9
Inspecting mother-to-infant microbiota transmission: disturbance of strain inheritance by cesarian section.检查母婴微生物群传播：剖宫产对菌株遗传的干扰。
Front Microbiol. 2024 Feb 29;15:1292377. doi: 10.3389/fmicb.2024.1292377. eCollection 2024.
10
Assembly, stability, and dynamics of the infant gut microbiome are linked to bacterial strains and functions in mother's milk.婴儿肠道微生物群的组装、稳定性和动态变化与母乳中的细菌菌株及功能有关。
bioRxiv. 2024 Jan 28:2024.01.28.577594. doi: 10.1101/2024.01.28.577594.
Nat Biotechnol. 2019 Aug;37(8):852-857. doi: 10.1038/s41587-019-0209-9.
4
Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome.不同身体部位的母婴微生物传播塑造了发育中的婴儿肠道微生物组。
Cell Host Microbe. 2018 Jul 11;24(1):133-145.e5. doi: 10.1016/j.chom.2018.06.005.
5
Maturation of the gut microbiome and risk of asthma in childhood.肠道微生物组的成熟与儿童哮喘的风险。
Nat Commun. 2018 Jan 10;9(1):141. doi: 10.1038/s41467-017-02573-2.
6
Quantifying the human vaginal community state types (CSTs) with the species specificity index.用物种特异性指数量化人类阴道群落状态类型（CSTs）。
PeerJ. 2017 Jun 27;5:e3366. doi: 10.7717/peerj.3366. eCollection 2017.
7
Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life.生命第一年期间古菌、细菌和微真核生物在人类肠道微生物群中的定殖与演替
Front Microbiol. 2017 May 2;8:738. doi: 10.3389/fmicb.2017.00738. eCollection 2017.
8
Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome.母乳细菌群落与婴儿肠道微生物群的建立和发育之间的关联
JAMA Pediatr. 2017 Jul 1;171(7):647-654. doi: 10.1001/jamapediatrics.2017.0378.
9
Studying Vertical Microbiome Transmission from Mothers to Infants by Strain-Level Metagenomic Profiling.通过菌株水平宏基因组分析研究母婴间垂直微生物群落传播
mSystems. 2017 Jan 17;2(1). doi: 10.1128/mSystems.00164-16. eCollection 2017 Jan-Feb.
10
Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery.婴儿微生物群落结构和功能在多个身体部位的成熟情况以及与分娩方式的关系。
Nat Med. 2017 Mar;23(3):314-326. doi: 10.1038/nm.4272. Epub 2017 Jan 23.