Jat Pooja Kumari, Dabaria Kamlesh Kumar, Bai Rekha, Yadav Lalit, Badsara Satpal Singh
MFOS Laboratory, Department of Chemistry, University of Rajasthan, JLN Marg, Jaipur, Rajasthan 302004, India.
J Org Chem. 2022 Oct 7;87(19):12975-12985. doi: 10.1021/acs.joc.2c01524. Epub 2022 Sep 15.
An interesting electrochemical direct bisarylation of carbonyls with indole derivatives to afford the corresponding bis(indolyl)methane (BIM) derivatives is described. The developed protocol is suitable for aliphatic, aromatic, and heteroaromatic aldehydes, which react with various electron-rich and electron-poor indoles to afford the corresponding BIMs in good to excellent yields. Isatin derivatives also underwent bisarylation with various indole derivatives under the influence of current to afford the corresponding BIMs in excellent yields.
本文描述了一种有趣的电化学方法，即羰基与吲哚衍生物直接进行双芳基化反应，以得到相应的双（吲哚基）甲烷（BIM）衍生物。所开发的方法适用于脂肪族、芳香族和杂芳香族醛，这些醛与各种富电子和贫电子吲哚反应，以良好至优异的产率得到相应的BIMs。在电流影响下，异吲哚酮衍生物也能与各种吲哚衍生物进行双芳基化反应，以优异的产率得到相应的BIMs。
