LAQV@REQUIMTE, Departamento de Química, NOVA School of Science and Technology, Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Portugal.
LAQV@REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
ChemistryOpen. 2023 Jan;12(1):e202200265. doi: 10.1002/open.202200265.
The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.
吲哚部分是天然产物中一种重要的 N-杂环，也是许多高附加值化学品的关键结构组成部分，包括药物。特别是，双（3-吲哚基）甲烷（BIMs）是吲哚的一个重要亚组，由两个吲哚单元组成。在此，我们报告了一种通过吲哚和苄醇的 tBuOK 介导偶联反应来获得 BIMs 衍生物的简单方法，该方法的产率高达 77%。
