Zatsepin E P, Churaev N N
Biull Eksp Biol Med. 1987 Aug;104(8):195-7.
The effect of central M- and N-cholinolytics on Fe++-ascorbate-dependent lipid peroxidation (LP) in the rat brain homogenate was studied in vitro. Central N-cholinolytics were shown to inhibit LP. Pediphen was the most active drug. Central M-cholinolytics were not active. Pediphen and an antioxidant ionol equally decreased LP in the rat brain after carbon tetrachloride intoxication (3 ml/kg). Ionol and pediphen had N- and not M-cholinolytic effect. It is suggested that membrane stabilization by N-cholinolytics is dependent on the antioxidant effect of the drugs. These data show an important role of LP in the function of cholinergic system.
体外研究了中枢性M和N胆碱能阻滞剂对大鼠脑匀浆中Fe++-抗坏血酸依赖性脂质过氧化（LP）的影响。中枢性N胆碱能阻滞剂可抑制LP。苯海拉明是最有效的药物。中枢性M胆碱能阻滞剂无活性。在四氯化碳中毒（3 ml/kg）后，苯海拉明和抗氧化剂离子醇同样降低了大鼠脑中的LP。离子醇和苯海拉明具有N胆碱能阻滞作用而非M胆碱能阻滞作用。提示N胆碱能阻滞剂的膜稳定作用依赖于药物的抗氧化作用。这些数据表明LP在胆碱能系统功能中起重要作用。
