Semenov E V
Biull Eksp Biol Med. 1982 May;93(5):66-8.
Experiments on rats were made to study the effect of cholinolytics and cholinomimetics on 33Na neuronal incorporation in different regions of the brain. Amizyl and glipin increased 22Na incorporation into the neurones of the hypothalamus and striatum and lowered membrane permeability of brain cortex neurones. Diphacil (trasentine) and tropacin inhibited 22Na neuronal incorporation in the brain cortex and did not change membrane permeability of the nerve cells of other structures. Arecoline increased membrane permeability of the neurones of all the brain regions studied. It is suggested that the neurotropic substances have selective action on membrane permeability of neurones in different regions of the rat brain.
在大鼠身上进行了实验，以研究抗胆碱药和拟胆碱药对大脑不同区域33Na神经元摄取的影响。阿米齐尔和格列平增加了22Na在下丘脑和纹状体神经元中的摄取，并降低了大脑皮质神经元的膜通透性。地芬明（曲司氯铵）和托哌西丁抑制大脑皮质中22Na神经元摄取，且不改变其他结构神经细胞的膜通透性。槟榔碱增加了所研究的所有脑区神经元的膜通透性。提示这些神经活性物质对大鼠脑不同区域神经元的膜通透性具有选择性作用。
